BONE CANCERS
BONE CANCERS
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DOI：
10.1002/1097-0142(19950101)75:1
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发表时间：
1995-01-01
期刊：
影响因子：
6.2
通讯作者：
CZERNIAK, B
中科院分区：
文献类型：
--
作者：
DORFMAN, HD;CZERNIAK, B
背景原发性骨肉瘤的频率分布数据长期以来一直被用来提供线索，以诊断骨癌后，他们在X线片鉴定，年龄和骨骼部位往往是有帮助的，除了特定的放射学特征，在缩小可能的组织学类别的骨肿瘤活检前。根据1973-1987年SEER计划收集的所有病例，按年龄、性别、种族和解剖部位进行分析。骨肉瘤是最常见的原发性骨肉瘤（35.1%），其次是软骨肉瘤（25.8%）、尤因肉瘤（16.0%）、脊索瘤（8.4%）和恶性纤维组织细胞瘤，包括纤维肉瘤（5.6%）。在20岁以下的人中，最常见的骨肉瘤是骨肉瘤，其次是尤文氏肉瘤。软骨肉瘤是50岁以上人群中最常见的骨肿瘤。总的5年相对生存率如下：骨肉瘤41.0%，软骨肉瘤72.7%，尤文氏肉瘤41.2%，脉络膜瘤63.8%，恶性纤维组织细胞瘤42.9%。在1973-1987年期间，脉络膜炎患者和患有尤文氏肉瘤的白色女性患者的生存率有所提高，尤文氏肉瘤和脉络膜炎几乎只发生在白色人群中。SEER数据为评估骨肉瘤的发病率和生存率提供了独特的机会，骨肉瘤是一种罕见但高致死性的肿瘤，该分析的结果为这些癌症的诊断提供了有用的信息。
Background. Frequency distribution data for primary bone sarcomas have long been used to provide clues to the diagnosis of bone cancers after their identification in radiographs, Age and skeletal site are often helpful, in addition to specific radiographic features, in narrowing down the probable histologic categories of bone neoplasms before biopsy.Methods, Data on 2627 histologically confirmed primary malignant tumors of bone, as collected by the SEER program during the period 1973-1987, were analyzed by age, sex, race, and anatomical site.Results. Osteosarcoma was the most frequently diagnosed primary sarcoma of bone (35.1%), followed by chondrosarcoma (25.8%), Ewing's sarcoma (16.0%), chordoma (8.4%), and malignant fibrous histiocytoma, including fibrosarcoma (5.6%). The most frequently diagnosed sarcoma of bone in persons younger than age 20 was osteosarcoma, followed by Ewing's sarcoma. Chondrosarcoma was the most frequently diagnosed bone tumor in the population older than age 50.The overall 5-year relative survival rates were as follows: osteosarcoma, 41.0%; chondrosarcoma, 72.7%; Ewing's sarcoma, 41.2%; chordoma, 63.8%; and malignant fibrous histiocytoma, 42.9%. There was an improvement in the survival rates during the period 1973-1987 for patients with chordoma and for white female patients with Ewing's sarcoma, Ewing's sarcoma and chordoma occurred almost exclusively in the white population.Conclusions. SEER data provide a unique opportunity to evaluate the incidence and survival rates of bone sarcomas, which are uncommon but highly lethal tumors, The findings from this analysis provide information useful in the diagnosis of these cancers.