Low expression of SOCS-1 and SOCS-3 is a poor prognostic indicator for gastric cancer patients
Low expression of SOCS-1 and SOCS-3 is a poor prognostic indicator for gastric cancer patients
复制标题
SOCS-1和SOCS-3的低表达是胃癌患者预后不良的指标。
DOI：
10.1007/s00432-014-1838-5
复制
发表时间：
2015-03-01
影响因子：
3.6
通讯作者：
He, Yulong
中科院分区：
文献类型：
--
作者：
Li, Guanghua;Xu, Jianbo;He, Yulong
背景和目标炎症在胃癌（GC）的发生和进展中发挥着重要作用。细胞因子信号传导抑制因子 (SOCS)-1 和 SOCS-3 负向调节促炎细胞因子信号传导；然而，它们在 GC 中的预后意义仍不清楚。我们评估了 SOCS-1 和 SOCS-3 在 GC 中的临床病理相关性和预后意义。 方法 使用基因表达综合数据库的微阵列数据集，对 80 对胃肿瘤和邻近正常粘膜组织中的 SOCS-1 和 SOCS-3 mRNA 水平进行分析。通过单变量和多变量分析，探讨 SOCS-1 和 SOCS-3 免疫组化表达对 186 例连续接受根治性手术的胃癌患者的总生存期（OS）和无复发生存期（RFS）的预后影响。结果胃肿瘤组织中 SOCS-1 和 SOCS-3 mRNA 的表达水平低于匹配的正常粘膜。 SOCS-1 和 SOCS-3 高表达组的 OS 和 RFS 显着长于相应的低表达组 (p < 0.05)。与低同时 SOCS-1 和 SOCS-3 表达相比，高同时 SOCS-1 和 SOCS-3 表达与更长的 OS 相关（68.8 个月与 22.2 个月；p < 0.001）。 SOCS-1 [风险比 (HR) 0.54，95% 置信区间 (CI) 0.33-0.87，p = 0.011] 和 SOCS-3（HR 0.46，95% CI 0.26-0.80，p = 0.006）是 OS 的独立预后因素。只有 SOCS-1 (HR 0.20, 95 % CI 0.11-0.38, p = 0.006) 是 RFS 的独立预后因素。结论 SOCS-1 和 SOCS-3 低表达是 GC 的不良预后指标。 SOCS-1和SOCS-3低表达的GC患者需要密切随访。
Background and objectives Inflammation plays an important role in gastric cancer (GC) development and progression. Suppressor of cytokine signaling (SOCS)-1 and SOCS-3 negatively regulate proinflammatory cytokine signaling; however, their prognostic significance in GC remains unknown. We evaluated the clinicopathological correlation and prognostic significance of SOCS-1 and SOCS-3 in GC.Methods SOCS-1 and SOCS-3 mRNA levels were analyzed in 80 paired gastric tumor and adjacent normal mucosal tissues using a microarray dataset from the Gene Expression Omnibus. Univariate and multivariate analyses were performed to investigate the prognostic impact of SOCS-1 and SOCS-3 immunohistochemical expression on overall survival (OS) and relapse-free survival (RFS) in 186 consecutive GC patients who underwent curative surgery.Results SOCS-1 and SOCS-3 mRNA expression levels were lower in gastric tumor tissues than in matched normal mucosa. OS and RFS were significantly longer in the high SOCS-1 and SOCS-3 expression groups than in their corresponding low expression groups (p < 0.05). High simultaneous SOCS-1 and SOCS-3 expression were associated with longer OS compared with low simultaneous SOCS-1 and SOCS-3 expression (68.8 vs. 22.2 months; p < 0.001). SOCS-1 [ hazards ratio (HR) 0.54, 95 % confidence interval (CI) 0.33-0.87, p = 0.011] and SOCS-3 (HR 0.46, 95 % CI 0.26-0.80, p = 0.006) were independent prognostic factors for OS. Only SOCS-1 (HR 0.20, 95 % CI 0.11-0.38, p = 0.006) was an independent prognostic factor for RFS.Conclusion Low SOCS-1 and SOCS-3 expression are poor prognostic indicators in GC. GC patients with low SOCS-1 and SOCS-3 expression need close follow-up.