Antioxidant vitamins supplementation and mortality:: A randomized trial in head and neck cancer patients
Antioxidant vitamins supplementation and mortality:: A randomized trial in head and neck cancer patients
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DOI：
10.1002/ijc.22042
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发表时间：
2006-11-01
影响因子：
6.4
通讯作者：
Tetu, Bernard
中科院分区：
文献类型：
--
作者：
Bairati, Isabelle;Meyer, Francois;Tetu, Bernard
人们一直担心，长期补充大剂量的抗氧化剂维生素，特别是维生素E(α-生育酚)，可能会增加全因死亡率。我们在540名接受放射治疗的头颈癌患者中进行了一项随机对照试验，补充α-生育酚(400IU/天)和β-胡萝卜素(30毫克/天)。在试验期间停止补充β-胡萝卜素。这些补充剂是在放射治疗期间给予的，并持续了3年。在随访期间(中位数为6.5年)，有179人死亡。所有的死亡证明都拿到了。通过COX回归分析比较两组患者的全因死亡率和特定原因死亡率。补充ARM：危险比：1.38，95%可信区间1.03-1.85，全因死亡率显著增加。补充剂组的特定原因死亡率往往高于安慰剂组。我们的结果与之前的报告一致，表明高剂量的维生素E可能是有害的。(C)2006年Wiley-Liss，Inc.
There has been concern that long-term supplementation with high-dose antioxidant vitamins, especially vitamin E (alpha-tocopherol), may increase all-cause mortality. We conducted a randomized controlled trial with alpha-tocopherol (400 IU/day) and beta-carotene (30 mg/day) supplements among 540 head and neck cancer patients treated by radiation therapy. Supplementation with beta-carotene was discontinued during the trial. The supplements were given during radiation therapy and for 3 additional years. During the follow-up (median 6.5 years), 179 deaths were recorded. All death certificates were obtained. All-cause and cause-specific mortality rates were compared between the 2 arms of the trial by Cox regression. All-cause mortality was significantly increased in the supplement arm: hazard ratio: 1.38, 95% confidence interval 1.03-1.85. Cause-specific mortality rates tended to be higher in the supplement arm than in the placebo arm. Our results concur with previous reports to suggest that high-dose vitamin E could be harmful. (c) 2006 Wiley-Liss, Inc.