The TOMM40 gene rs2075650 polymorphism contributes to Alzheimer's disease in Caucasian, and Asian populations
The TOMM40 gene rs2075650 polymorphism contributes to Alzheimer's disease in Caucasian, and Asian populations
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DOI：
10.1016/j.neulet.2016.05.050
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发表时间：
2016-08-15
影响因子：
2.5
通讯作者：
Chen, Bingwei
中科院分区：
文献类型：
--
作者：
Huang, Hao;Zhao, Jun;Chen, Bingwei
大规模全基因组关联研究（GWAS）显示，TOMM 40基因rs 2075650多态性与高加索人和亚洲人阿尔茨海默病（AD）显著相关。在这里，我们通过PubMed，AlzGene和Google Scholar评估了来自12项研究（N = 28，515; 10，358例病例和18，157例对照）的大规模样本的相关性。我们发现rs 2075650与AD之间存在显著相关性，P = 0.000，OR = 4.178，95%CI 1.891-9.228。在亚组分析中，我们发现rs 2075650多态性与亚洲人和高加索人的AD显著相关，但与混合人群无关。总的来说，我们的分析显示TOMM 40 rs 2075650多态性与亚洲人、高加索人和混合人群中的AD易感性相关。我们相信，我们的分析将有助于未来的遗传研究AD。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Largescale genome-wide association studies (GWAS) showed that the TOMM40 rs2075650 polymorphism is significantly associated with Alzheimer's disease (AD) in Caucasian ancestry and Asian population. Here, we evaluated this association with large-scale samples from selected 12 studies (N = 28,515; 10,358 cases and 18,157 controls) through the PubMed, AlzGene, and Google Scholar. We identified a significant association between rs2075650 and AD with P = 0.000, OR = 4.178 and 95% CI 1.891-9.228. In subgroup analysis, we identified significant association between rs2075650 polymorphism and AD in both Asian and Caucasians but not mixed populations. Collectively, our analysis shows TOMM40 rs2075650 polymorphism is associated with AD susceptibility in Asian, Caucasian, and mixed populations. We believe that our analysis will be helpful for future genetic researches on AD. (C) 2016 Elsevier Ireland Ltd. All rights reserved.