Efficacy of duloxetine for multisite pain in patients with knee pain due to osteoarthritis: An exploratory post hoc analysis of a Japanese phase 3 randomized study
Efficacy of duloxetine for multisite pain in patients with knee pain due to osteoarthritis: An exploratory post hoc analysis of a Japanese phase 3 randomized study
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DOI：
10.1016/j.jos.2020.02.013
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发表时间：
2021-02-18
影响因子：
1.7
通讯作者：
Uchio, Yuji
中科院分区：
文献类型：
--
作者：
Itoh, Naohiro;Tsuji, Toshinaga;Uchio, Yuji
Background: Central sensitization, including dysfunction of descending inhibitory pain pathways, may contribute to multisite pain in patients with chronic musculoskeletal conditions. Duloxetine is a centrally acting analgesic that effectively reduces pain in patients with knee osteoarthritis. Here we assessed the efficacy of duloxetine (60 mg/day) in Japanese patients (N = 353) with pain due to knee osteoarthritis based on the number of painful body sites, determined using the Michigan Body Map.Methods: Post hoc analysis of a phase 3, randomized, placebo-controlled trial (CinicalTrials.gov;NCT02248480).Results: At Week 14, the change from baseline in Brief Pain Inventory-Severity average pain score ("pain reduction") was significantly greater with duloxetine compared with placebo in patients with 3, 4, or >= 5 painful sites, but not in patients with 1 or 2 painful sites. In patients with >= 3 painful sites (57% of patients), pain reduction was significantly greater with duloxetine (n = 100) compared with placebo (n = 101) throughout the study (least squares mean change from baseline to Week 14: -2.68 vs -1.68). Greater pain reduction with duloxetine (n = 77) than placebo (n = 75) also occurred in patients with
