Regulation of Müller glial dependent neuronal regeneration in the damaged adult zebrafish retina.
Regulation of Müller glial dependent neuronal regeneration in the damaged adult zebrafish retina.
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DOI：
10.1016/j.exer.2013.07.012
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发表时间：
2014-06
影响因子：
3.4
通讯作者：
Hyde, David R.
中科院分区：
文献类型：
--
作者：
Gorsuch, Ryne A.;Hyde, David R.
这篇文章考察了我们目前对成年斑马鱼视网膜参与神经元再生的机制的了解。斑马鱼具有再生多种组织和器官(包括鳍、肾、心脏、脑和脊髓)的能力，由于其反应的健壮性和速度以及可用于研究这一问题的各种遗传工具，已成为研究视网膜再生的主要模型系统。目前已有文献证明，视网膜损伤可诱导常驻的Müler胶质细胞去分化并重新进入细胞周期，从而产生神经前体细胞，继续增殖，迁移到受损的视网膜层，并分化为缺失的神经细胞类型。增加我们对这些细胞事件是如何调节和发生在神经元损伤反应中的理解，可能会提供关键的信息，这些信息可以用于刺激哺乳动物视网膜的再生反应。在这篇综述中，我们将集中在调控斑马鱼视网膜再生的基因/蛋白质上，并试图批判性地评估这些因素如何相互作用，正确地协调再生过程中发生的决定性细胞事件。
This article examines our current knowledge underlying the mechanisms involved in neuronal regeneration in the adult zebrafish retina. Zebrafish, which has the capacity to regenerate a wide variety of tissues and organs (including the fins, kidney, heart, brain, and spinal cord), has become the premier model system to study retinal regeneration due to the robustness and speed of the response and the variety of genetic tools that can be applied to study this question. It is now well documented that retinal damage induces the resident Müller glia to dedifferentiate and reenter the cell cycle to produce neuronal progenitor cells that continue to proliferate, migrate to the damaged retinal layer and differentiate into the missing neuronal cell types. Increasing our understanding of how these cellular events are regulated and occur in response to neuronal damage may provide critical information that can be applied to stimulating a regeneration response in the mammalian retina. In this review, we will focus on the genes/proteins that regulate zebrafish retinal regeneration and will attempt to critically evaluate how these factors may interact to correctly orchestrate the definitive cellular events that occur during regeneration.
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DOI：
10.1002/cne.22243
发表时间：
2010-03-15
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Montgomery JE;Parsons MJ;Hyde DR
通讯作者：
Hyde DR
影响因子：
5.3
作者：
Fausett, Blake V.;Gumerson, Jessica D.;Goldman, Daniel
通讯作者：
Goldman, Daniel
影响因子：
4.2
作者：
Kim, Seung-Woo;Lee, Ja-Kyeong
通讯作者：
Lee, Ja-Kyeong
影响因子：
5.3
作者：
Bernardos, Rebecca L.;Barthel, Linda K.;Raymond, Pamela A.
通讯作者：
Raymond, Pamela A.
影响因子：
4.4
作者：
Morris, Ann C.;Forbes-Osborne, Marie A.;Fadool, James M.
通讯作者：
Fadool, James M.