Adverse effects of high-dose interferon-α-2a treatment for chronic hepatitis B
Adverse effects of high-dose interferon-α-2a treatment for chronic hepatitis B
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DOI：
10.1007/bf02877700
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发表时间：
2007-09-01
影响因子：
3.8
通讯作者：
Usluer, Gaye
中科院分区：
文献类型：
--
作者：
Kartal, Elif Doyuk;Nayman, Saygin;Usluer, Gaye
本研究的目的是评估慢性B型肝炎患者接受干扰素（IFN）-α-2a治疗期间的发病率和不良反应发生率。这项前瞻性研究纳入了48名连续的慢性B型肝炎患者，他们在2003年1月至2005年8月期间接受了IFN-α-2a治疗。在此期间和治疗后6个月记录与IFN治疗相关的不良反应。检查了导致剂量减少或早期中断IFN治疗的不良反应。25%的患者报告完全缓解。88%的患者记录了至少一种不良反应。流感样症状是最常见的不良反应（88%），还报告了血小板减少症（63%）、白细胞减少症（54%）和贫血（23%）。2例患者发生出血。其他不良反应包括神经精神症状（21%）、脱发（19%）、体重减轻（17%）、甲状腺疾病（19%）、月经周期不规则（8%）、皮肤病变（8%）和干咳（4%）。19%的患者发生了导致剂量减少或早期中断IFN治疗的不良反应，包括阳痿、抑郁、癫痫发作、甲状腺疾病、严重血小板减少症和肠道出血。发现这些效应与治疗反应无关。未发现患者年龄、治疗持续时间和IFN不良反应之间存在相关性。尽管IFN-α-2a治疗在慢性B型肝炎患者中引起了各种不良反应，但大多数这些反应是可逆的或可以改善的。不良反应导致剂量减少或早期中断干扰素治疗被认为是无关的完全响应。
The aim of this study was to assess morbidity and the incidence of adverse effects during interferon (IFN)-alpha-2a treatment of patients with chronic hepatitis B. This prospective study included 48 consecutive patients with chronic hepatitis B who underwent IFN-alpha-2a treatment from January 2003 to August 2005. Adverse effects related to IFN treatment were recorded during this period and for 6 mo after treatment. Adverse effects that led to dose reduction or early discontinuation of IFN treatment were examined. Complete response was reported in 25% of patients. At least I adverse effect was documented in 88% of patients. Flu-like symptoms were the most frequently observed adverse effects (88%), and thrombocytopenia (63%), leukopenia (54%), and anemia (23%) were also reported. Bleeding occurred in 2 patients. Other adverse effects included neuropsychiatric signs (21%), alopecia (19%), weight loss (17%), thyroid disorders (19%), menstrual cycle irregularities (8%), skin lesions (8%), and dry cough (4%). Adverse effects that led to dose reduction or early discontinuation of IFN treatment occurred in 19% of patients and included impotence, depression, seizure, thyroid disorders, severe thrombocytopenia, and intestinal bleeding. These effects were found to be unrelated to treatment response. No relationship was detected between patient age, duration of treatment, and adverse effects of IFN. Although IFN-alpha-2a treatment induced various adverse effects in patients with chronic hepatitis B, most of these effects were reversible or could be ameliorated. Adverse effects that led to dose reduction or early discontinuation of IFN treatment were found to be unrelated to complete response.