Serologic diagnosis of acute lymphadenopathic toxoplasmosis.
Serologic diagnosis of acute lymphadenopathic toxoplasmosis.
复制标题
急性淋巴结病弓形虫病的血清学诊断。
DOI：
10.1093/infdis/142.2.256
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Remington,JS
中科院分区：
文献类型：
--
作者：
Welch,PC;Masur,H;Jones,TC;Remington,JS
急性弓形虫病的诊断通常依赖于血清学，但很少有数据可用于比较发病后各种血清学试验的相对有用性。Sabin-Feldman染料试验（DT），IgM免疫荧光抗体（IgMIFA）试验，可溶性抗原补体结合（CF）试验，和间接血凝（IHA）试验进行了系列血清标本从27个以前健康的患者，每个人都可以确定发病日期在两周内。IgM-IFA滴度≥ 1：160是过去2 - 4个月获得感染的最佳指标。DT对于筛查是有用的，但很少记录到两管滴度升高，绝对滴度是最近感染的不精确指标。虽然在CF和IHA试验中可以看到大多数患者的滴度双管上升，但上升速度如此缓慢，以至于这两种试验在记录急性弓形虫病的诊断方面不如IgMIFA试验有用。
The diagnosis of acute toxoplasmosis usually depends on serology, yet little data are available to compare the relative usefulness of various serologic tests after the onset of illness. The Sabin-Feldman dye test (DT), the IgM immunofluorescent antibody (IgMIFA) test, the soluble antigen complement-fixation (CF) test, and the indirect hemagglutination (IHA) test were performed on serial serum specimens from 27 previously healthy patients, each of whom could identify the date of onset of illness within two weeks. IgM-IFA titers of ⩾1:160 were the best indicators of infection acquired in the past two to four months. The DT was useful for screening, but two-tube rises in titer were rarely documented, and absolute titers were imprecise indicators of the recentness of infection. Although two-tube rises in titer in CF and IHA tests could be seen in the majority of patients, the rises were so slow that both tests were less useful than the IgMIFA test in documenting the diagnosis of acute toxoplasmosis.