Gut microbiota, inflammation and colorectal cancer.
Gut microbiota, inflammation and colorectal cancer.
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肠道菌群，炎症和结直肠癌。
DOI：
10.1016/j.gendis.2016.03.004
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发表时间：
2016-06
期刊：
影响因子：
6.8
通讯作者：
Kato I
中科院分区：
文献类型：
--
作者：
Sun J;Kato I
虽然基因有助于结直肠癌，但肠道微生物区系是一个重要的参与者。越来越多的证据表明，慢性感染和随之而来的炎症有助于肿瘤的发生和发展。各种细菌种类和促进肿瘤毒力的机制已经被研究。在了解肠道微生物区系的组成和功能及其在癌症中的作用方面取得了重大进展。在目前的综述中，我们讨论了微生物区系在结肠癌进展中的新作用。虽然从技术上讲，微生物区系包括细菌以外的生物，如病毒和真菌，但本综述将主要集中在细菌上。我们总结了人类微生物群和结肠癌的流行病学研究。我们讨论了在实验模型中肠道微生物区系、屏障功能和宿主反应之间相互作用的科学理解的进展。此外，我们还讨论了以微生物区系为靶点在结肠癌预防、诊断和治疗中的潜在应用。我们讨论了结肠癌肠道微生物组研究面临的挑战和未来的方向，以缩小基础科学和临床应用之间的差距。
Although genes contribute to colorectal cancer, the gut microbiota are an important player. Accumulating evidence suggests that chronic infection and the ensuing inflammation contributes to tumor initiation and tumor progression. A variety of bacterial species and tumor-promoting virulence mechanisms have been investigated. Significant advances have been made in understanding the composition and functional capabilities of the gut microbiota and its roles in cancer. In the current review, we discuss the novel roles of microbiota in the progression of colon cancer. Although microbiota technically include organisms other than bacteria e.g., viruses and fungi, this review will primarily focus on bacteria. We summarize epidemiological studies of human microbiome and colon cancer. We discuss the progress in the scientific understanding of the interplay between the gut microbiota, barrier function, and host responses in experimental models. Further, we discuss the potential application in prevention, diagnosis, and therapy of colon cancer by targeting microbiota. We discuss the challenges lie ahead and the future direction in studying gut microbiome in colon cancer to close the gap between the basic sciences and clinical application.