SECRETION AND MOVEMENT OF WINGLESS PROTEIN IN THE EPIDERMIS OF THE DROSOPHILA EMBRYO
SECRETION AND MOVEMENT OF WINGLESS PROTEIN IN THE EPIDERMIS OF THE DROSOPHILA EMBRYO
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DOI：
10.1016/0925-4773(91)90040-d
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发表时间：
1991-08-01
影响因子：
2.6
通讯作者：
ARIAS, AM
中科院分区：
文献类型：
--
作者：
GONZALEZ, F;SWALES, L;ARIAS, AM
片段极性基因wingless编码一种富含半胱氨酸的蛋白质，该蛋白质是果蝇模式形成所必需的。 使用多克隆抗体对无翅基因的产品，我们证明，这种蛋白质是在胚胎中分泌，它是由邻近的细胞。 这种蛋白质可以在距离合成它的细胞两到三个细胞直径的地方找到。 我们讨论了可能的机制，负责这种空间分布和调控胚胎发生过程中。
The segment polarity gene wingless encodes a cysteine rich protein which is essential for pattern formation in Drosophila. Using polyclonal antibodies against the product of the wingless gene, we demonstrate that this protein is secreted in the embryo and that it is taken up by neighbouring cells. The protein can be found two or three cell diameters away from the cells in which it is synthesized. We discuss the possible mechanisms which are responsible for this spatial distribution and its regulation during embryogenesis.