Verapamil, propranolol, and hydralazine protect against the acute cardiac depression induced by adriamycin.
Verapamil, propranolol, and hydralazine protect against the acute cardiac depression induced by adriamycin.
复制标题
维拉帕米、普萘洛尔和肼屈嗪可预防阿霉素引起的急性心脏抑制。
DOI：
10.1093/cvr/17.1.43
复制
发表时间：
1983
影响因子：
10.8
通讯作者：
Parmley,WW
中科院分区：
文献类型：
--
作者：
Wikman-Coffelt,J;Rapcsak,M;Sievers,R;Rouleau,JL;Parmley,WW
心尖喷射离体大鼠心脏用含有 3 × 10−5mol·litre−1 阿霉素的介质灌注 40 分钟，显示出收缩模式的以下变化：（a）舒张末期压力增加 10 倍：（b）发展压力降低 45％； (c) 冠状动脉流量减少 17%； (d) 达到峰值压力的时间增加 27%； (e) 放松期间压力下降 50% 的时间增加 26%； (f) 最大 (+) 和 (−) dP/dt 降低 65%。在死亡前 1 小时预处理的大鼠中，维拉帕米、普萘洛尔和肼屈嗪显着减轻了阿霉素产生的心脏抑制作用。维拉帕米和肼苯哒嗪的组合，或普萘洛尔和肼苯哒嗪的组合尤其有效。特别引人注目的是针对舒张压增加提供的保护。地高辛预处理没有提供保护。据推测，阿霉素的急性抑郁作用可能与钙超载有关。
The apex ejecting isolated rat heart perfused with media containing 3 × 10−5mol·litre−1adriamycin for 40 min demonstrated the following changes in contraction patterns: (a) a ten-fold increase in end-diastolic pressure: (b) a 45% decrease in developed pressure; (c) a 17% decrease in coronary flow; (d) a 27% increase in time to peak pressure; (e) a 26% increase in time for pressure to fall 50% during relaxation; and (f) a 65% decrease in maximum (+) and (−) dP/dt. In rats pretreated 1 h before death, verapamil, propranolol, and hydralazine significantly attenuated the cardiac depression produced by adriamycin. The combinations of verapamil and hydralazine, or propranolol and hydralazine were especially efficacious. Particularly striking was the protection afforded against an increase in diastolic pressure. Digoxin pretreatment afforded no protection. It is postulated that the acute depressive effects of adriamycin may be related to calcium overload.