Immunosuppressive HLA-G molecule is upregulated in alveolar epithelial cells after influenza A virus infection
Immunosuppressive HLA-G molecule is upregulated in alveolar epithelial cells after influenza A virus infection
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DOI：
10.1016/j.humimm.2009.07.026
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发表时间：
2009-12-01
期刊：
影响因子：
2.7
通讯作者：
Riteau, Beatrice
中科院分区：
文献类型：
--
作者：
LeBouder, Fanny;Khoufache, Khaled;Riteau, Beatrice
A型流感病毒感染构成了一个重要的经济负担，并引起了保健问题。宿主防御机制通常在几天后通过利用各种细胞免疫应答来清除IAV感染。然而，增加免疫破坏分子的产生是病毒逃避宿主监视的机制。在这方面，非经典HLA I类分子HLA-G显示出强的致耐受性特性。我们在这里表明，不同的IAV株上调HLA-G的表达，在mRNA和蛋白质水平，在肺泡上皮细胞。因此，IAV的毒力可能是由不同毒株上调HLA-G的能力引起的，从而使它们逃避宿主免疫应答。(C)2009年美国组织相容性和免疫遗传学学会。爱思唯尔公司出版All rights reserved.
Influenza virus type A (IAV) infections constitute an important economic burden and raise health-care problems. Host defense mechanisms usually clear IAV infections after a few days by exploiting a variety of cellular immune responses. However, increasing the production of immunosubversive molecules is a mechanism by which viruses escape host surveillance. In this regard, the nonclassical HLA class I molecule HLA-G displays strong tolerogenic properties. We show here that several strains of IAV differently upregulate HLA-G expression, at both the mRNA and protein levels, in alveolar epithelial cells. Thus the virulence of IAV may be caused by the capability of different strains to upregulate HLA-G allowing their escape from host immune responses. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.