A 9-mo randomized clinical trial comparing fat-substituted and fat-reduced diets in healthy obese men: the Ole Study
A 9-mo randomized clinical trial comparing fat-substituted and fat-reduced diets in healthy obese men: the Ole Study
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DOI：
10.1093/ajcn/76.5.928
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发表时间：
2002-11-01
影响因子：
7.1
通讯作者：
Peters, JC
中科院分区：
文献类型：
--
作者：
Bray, GA;Lovejoy, JC;Peters, JC
背景：膳食脂肪已被认为是心血管疾病和肥胖的危险因素。目的：我们评估中度肥胖男性用橄榄油替代膳食脂肪对体重、体脂、脂质、葡萄糖和胰岛素的影响。设计：45名健康的超重男性被随机分配到三种饮食中的一种：控制饮食（33%脂肪）、减脂饮食（25%脂肪）或脂肪替代饮食（用奥利斯特拉代替三分之一的膳食脂肪，以达到含有25%代谢脂肪的饮食）。用双能x线吸收仪测量体脂，用计算机断层扫描测量内脏和皮下腹部脂肪。结果：36名男性完成了为期9个月的研究。在9个月的时间里，脂肪替代组的体重和体脂平均下降幅度分别为6.27 +/- 1.66和5.85 +/- 1.34 kg，对照组为3.8 +/- 1.34和3.45 +/- 1.0 kg，减脂组为1.79 +/- 0.81和1.68 +/- 0.75 kg。9个月时，减脂组和减脂组体脂平均差值为-4.19 +/- 1.19 kg (95% CI: -6.57, -1.81)，对照组和减脂组体脂平均差值为-2.55 +/- 1.21 kg(-0.13, -4.97)，对照组和减脂组体脂平均差值为1.63 +/- 1.18 kg（3.96, -0.70）。吃低脂饮食的男性几乎没有要求额外的食物，而其他两组的要求明显更高（P < 0.05）。结论：与脂肪含量为25%的饮食或脂肪含量为33%的对照饮食相比，用奥氏酯替代膳食脂肪可降低体重和总脂肪。
Background: Dietary fat has been implicated as a risk factor for cardiovascular disease and obesity.Objective: We evaluated the effect on body weight, body fat, lipids, glucose, and insulin of replacing dietary fat with olestra in moderately obese men.Design: Forty-five healthy overweight men were randomly assigned to 1 of 3 diets: control diet (33% fat), fat-reduced diet (25% fat), or fat-substituted diet (one-third of dietary fat replaced by olestra to achieve a diet containing 25% metabolizable fat). Body fat was measured by dual-energy X-ray absorptiometry and visceral and subcutaneous abdominal fat by computed tomography.Results: Thirty-six men completed the 9-mo study. Body weight and body fat in the fat-substituted group declined by a mean ( SEM) of 6.27 +/- 1.66 and 5.85 +/- 1.34 kg, respectively, over 9 mo compared with 3.8 +/- 1.34 and 3.45 +/- 1.0 kg in the control group and 1.79 +/- 0.81 and 1.68 +/- 0.75 kg in the fat-reduced diet group. At 9 mo, the mean difference in body fat between the fat-reduced and fat-substituted groups was -4.19 +/- 1.19 kg (95% CI: -6.57, -1.81), that between the control and fat-substituted groups was -2.55 +/- 1.21 kg (-0.13, -4.97), and that between the control and fat-reduced groups was 1.63 +/- 1.18 kg (3.96, -0.70). The men eating the fat-reduced diet asked for almost no extra foods, in contrast with the significantly higher requests (P < 0.05) from both of the other 2 groups.Conclusion: Replacement of dietary fat with olestra reduces body weight and total body fat when compared with a 25%-fat diet or a control diet containing 33% fat.