Increases in Acute Hepatitis C Virus Infection Related to a Growing Opioid Epidemic and Associated Injection Drug Use, United States, 2004 to 2014
Increases in Acute Hepatitis C Virus Infection Related to a Growing Opioid Epidemic and Associated Injection Drug Use, United States, 2004 to 2014
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DOI：
10.2105/ajph.2017.304132
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发表时间：
2018-02-01
影响因子：
12.7
通讯作者：
Holtzman, Deborah
中科院分区：
文献类型：
--
作者：
Zibbell, Jon E.;Asher, Alice K.;Holtzman, Deborah
目标.比较美国的注射药物使用率（IDU）趋势，特别是阿片类药物注射，与急性HCV感染发生率的国家趋势，以评估这些事件是否随时间而相关。我们使用2004年至2014年的监测数据计算了急性HCV感染的年发病率和人口统计学和风险特征或报告病例，并按类型或注射药物和人口统计学特征计算了同期报告IDU的物质使用障碍治疗机构的年入院率。然后，Ode测试了趋势。从7004年到2014年，急性HCV感染的年发病率增加了2倍以上（从0.3例/10万增加到07例/10万），在选定的人口统计学亚组中显著增加。因注射海洛因和处方阿片类镇痛药导致的物质使用障碍的入院率显著增加，处方阿片类镇痛药注射增加近4倍。阿片类药物注射的显著增加反映了人口统计学亚组中报告的急性HCV感染病例。这些研究结果强烈表明，全国急性HCV感染的增加与该国的阿片类药物流行和相关的注射吸毒增加有关。
Objectives. To compare US trends in rates or injection drug use (IDU), specifically opioid injection, with national trends in the incidence of acute HCV infection to assess whether these events correlated over time.Methods. We calculated the annual incidence rate and demographic and risk characteristics or reported cases of acute HCV infection using surveillance data From 2004 to 2014 and the annual percentage of admissions to substance use disorder treatment Facilities reporting IDU For the same time period by type or drug injected and demographic characteristics. Ode then tested for trends.Results. The annual incidence rate of acute HCV infection increased more than 2-Fold (from 0.3 to 07 cases/100 000) From 7004 to 2014, with significant increases among, select demographic subgroups. Admissions for substance use disorder attributed to injection of heroin and prescription opioid analgesics increased significantly, with an almost 4-Fold increase in prescription opioid analgesic injection. Significant increases in opioid injection mirrored those For reported cases of acute HCV infection among demographic subgroups.Conclusions. These findings strongly suggest that the national increase in acute HCV infection is related to the country's opioid epidemic and associated increases in IDU.