A new class of branched aminoglycosides: Pseudo- pentasaccharide derivatives of neomycin B
A new class of branched aminoglycosides: Pseudo- pentasaccharide derivatives of neomycin B
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DOI：
10.1021/ol035213i
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发表时间：
2003-10-02
期刊：
影响因子：
5.2
通讯作者：
Baasov, T
中科院分区：
文献类型：
--
作者：
Fridman, M;Belakhov, V;Baasov, T
通过在β-构型中添加一个额外的糖环来修饰临床上重要的抗生素新霉素B的位置C5”，并且针对各种细菌菌株（包括致病性菌株和抗性菌株）测试所观察到的假戊糖。所设计的抗生素对病原菌和耐药菌株的抗菌活性上级于新霉素B。
The clinically important antibiotic neomycin B was modified at position C5" by adding one extra sugar ring in the beta-configuration, and the observed pseudo-pentasaccharides were tested against various bacterial strains, including pathogenic and resistant strains. The designed antibiotics show antibacterial activity superior to that of neomycin B against pathogenic and resistant bacterial strains.