PREVALENCE OF VISUAL DEFICITS IN ALZHEIMERS-DISEASE
PREVALENCE OF VISUAL DEFICITS IN ALZHEIMERS-DISEASE
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DOI：
10.1097/00006324-199503000-00003
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发表时间：
1995-03-01
影响因子：
1.4
通讯作者：
GROWDON, JH
中科院分区：
文献类型：
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作者：
MENDOLA, JD;CRONINGOLOMB, A;GROWDON, JH
本研究探讨了77名阿尔茨海默病（AD）患者和111名健康对照者的视力缺陷的患病率和模式。 我们定义了100名对照受试者中仅1名受试者的预期临界评分（p = 0.01）。 在16项视觉测试中，表现达到或低于该水平的AD受试者百分比从58%的高到0%的低不等。 测试之间的损害的分布表明AD的图案视觉的高度脆弱性，空间视觉的中度脆弱性，以及运动和闪烁感知的低脆弱性。 我们发现了AD受试者组异质性的证据：出现了一个亚组（N = 14），其特征是在反向模式掩蔽测试中表现不佳，年龄相对较小，AD持续时间相对较短。 总体而言，结果表明视觉功能障碍，特别是向后掩蔽，是AD的常见体征。
This study addressed the issue of prevalence and pattern of visual deficits in 77 subjects with Alzheimer's disease (AD) and 111 healthy control subjects. We defined cutoff scores that would be expected from only 1 control subject of 100 (p = 0.01). The percentage of AD subjects who performed at or worse than this level varied across the 16 visual tests from a high of 58% to a low of 0%. The distribution of impairment across tests suggests a high vulnerability in AD of pattern vision, moderate vulnerability of spatial vision, and low vulnerability of motion and flicker perception. We found evidence for heterogeneity in the AD subject group: a subgroup (N = 14) emerged that was characterized by poor performance on the Backward Pattern Masking test, relatively young age, and relatively short duration of AD. Overall, the results indicate that visual dysfunction, especially on Backward Masking, is a common sign of AD.