Nutritional manipulations and tumor growth. I. The effects of starvation.
Nutritional manipulations and tumor growth. I. The effects of starvation.
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营养操作和肿瘤生长。
DOI：
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发表时间：
1979
影响因子：
7.1
通讯作者：
M. Brennan
中科院分区：
文献类型：
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作者：
J. Goodgame;S. Lowry;J. Reilly;D. Jones;M. Brennan
饥饿对肿瘤和宿主生长的影响进行了研究，在生长的雄性Fischer大鼠轴承甲基胆蒽诱导的肉瘤。通过重量、体积和氚化甲基胸苷掺入肿瘤DNA（dpm/微克DNA）的变化评价肿瘤生长。宿主生长之后是总体重、胴体重和dpm/微克肝脏DNA的变化。饥饿的所有时期（24至96小时）引起的主机体和胴体重量和dpm/微克肝DNA显着下降。进食和饥饿动物的肿瘤重量和肿瘤体积变化相等。在48、72和96小时饥饿间隔时，饥饿动物中的肿瘤dpm/微克DNA相对于进食对照增加（P小于0.005）。饥饿允许肿瘤继续生长，同时发生宿主消耗，并伴随着该系统中肿瘤dpm/微克DNA的增加。
The effects of starvation on tumor and host growth were studied in growing male Fischer rats bearing methylcholanthrene-induced sarcomas. Tumor growth was evaluated by changes in weight, volume, and incorporation of tritiated methyl thymidine into tumor DNA, (dpm/microgram DNA). Host growth was followed by changes in total body weight, carcass weight, and dpm/microgram liver DNA. All periods of starvation (24 to 96 hr) caused significant decreases in host body and carcass weight and dpm/microgram liver DNA. Changes in tumor weight and tumor volume in fed and starved animals were equal. Tumor dpm/microgram DNA in starved animals increased (P less than 0.005) relative to fed controls at 48, 72, and 96 hr starvation intervals. Starvation allows continued tumor growth while host wasting occurs, and is accompanied by increased tumor dpm/microgram DNA in this system.