Mathematical modeling in cancer nanomedicine: a review
Mathematical modeling in cancer nanomedicine: a review
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DOI：
10.1007/s10544-019-0380-2
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发表时间：
2019-06-01
影响因子：
2.8
通讯作者：
Wang, Zhihui
中科院分区：
文献类型：
--
作者：
Dogra, Prashant;Butner, Joseph D.;Wang, Zhihui
癌症仍然是全球主要的医疗保健问题之一，人们不仅在继续努力寻找更好的药物，而且还在寻找更好的药物输送方法。为了提高安全性和有效性，需要将细胞毒性剂选择性地递送到癌细胞，这引发了纳米技术在医学中的应用。这一努力提供了可能彻底改变癌症治疗的药物递送系统。纳米载体由于其靶向药物递送的能力，可以将细胞毒性的平衡从健康细胞转移到癌细胞。癌症纳米医学领域已经取得了重大进展，但仍然存在阻碍其临床转化的挑战。存在将纳米载体运输到肿瘤的几个生物物理障碍，并且需要更深入地了解纳米生物相互作用以改变现状。数学建模有助于提高我们对生物系统中纳米材料行为的物理化学和生理学基础的理解。在这里，我们提出了一个全面的文献综述的数学建模工作，已经和正在对更好地理解纳米生物相互作用，提高肿瘤的输送效率。
Cancer continues to be among the leading healthcare problems worldwide, and efforts continue not just to find better drugs, but also better drug delivery methods. The need for delivering cytotoxic agents selectively to cancerous cells, for improved safety and efficacy, has triggered the application of nanotechnology in medicine. This effort has provided drug delivery systems that can potentially revolutionize cancer treatment. Nanocarriers, due to their capacity for targeted drug delivery, can shift the balance of cytotoxicity from healthy to cancerous cells. The field of cancer nanomedicine has made significant progress, but challenges remain that impede its clinical translation. Several biophysical barriers to the transport of nanocarriers to the tumor exist, and a much deeper understanding of nano-bio interactions is necessary to change the status quo. Mathematical modeling has been instrumental in improving our understanding of the physicochemical and physiological underpinnings of nanomaterial behavior in biological systems. Here, we present a comprehensive review of literature on mathematical modeling works that have been and are being employed towards a better understanding of nano-bio interactions for improved tumor delivery efficacy.