Auditory Verbal Learning Test is Superior to Rey-Osterrieth Complex Figure Memory for Predicting Mild Cognitive Impairment to Alzheimer's Disease
Auditory Verbal Learning Test is Superior to Rey-Osterrieth Complex Figure Memory for Predicting Mild Cognitive Impairment to Alzheimer's Disease
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DOI：
10.2174/1567205012666150530202729
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发表时间：
2015-01-01
影响因子：
2.1
通讯作者：
Hong, Zhen
中科院分区：
文献类型：
--
作者：
Zhao, Qianhua;Guo, Qihao;Hong, Zhen
目的：为了对不同的轻度认知障碍（MCI）研究结果进行有意义的比较，选择合适的客观记忆测验来检查记忆缺陷是至关重要的。我们的目标是完善遗忘型MCI（aMCI）的神经心理学测试的操作标准，最佳平衡的敏感性和特异性。方法：我们集中在206名非痴呆的记忆诊所。然后，我们根据不同的神经心理学标准将每个人分为MCI或主观认知下降（SCD）。通过纵向随访，比较临床结局，以评估MCI诊断的稳定性和进展预测。结果如下：听觉语言学习延迟回忆测验（AVLT_DR）将116名受试者确定为MCI，在大约30个月的时间间隔内转换率为44%，在SCD组中遗漏了7.8%的早期阿尔茨海默病（AD）患者最终转换为痴呆。与AVLT标准相比，延迟复杂图形回忆测验（CFT_DR）识别MCI患者较少（n=95），误诊临床前AD患者较多（15.3%）。两项试验均为缺陷的标准转换率较高（54.3%），但同时也导致较高的误诊率（14.7%）。AVLT标准的曲线下面积最大（0.7248，p
Objective: To carry out meaningful comparisons on results of different research studies on mild cognitive impairment (MCI), it is critical to select an appropriate objective memory test to examine memory deficit. We aim to refine the operational criteria of amnestic MCI (aMCI) on neuropsychological tests that optimally balance the sensitivity and specificity. Methods: We focused on 206 non-demented subjects from memory clinic. We then classified each individual as having MCI or subjective cognitive decline (SCD) according to different neuropsychological criteria. By following them longitudinally, clinical outcomes were compared to evaluate the stability of MCI diagnoses and prediction of progression. Results: The delayed recall of auditory verbal learning test (AVLT_DR) identified 116 subjects as MCI, resulted in the conversion rate as 44% over the roughly 30-month time interval, missed 7.8% incipient Alzheimer's disease (AD) patients in SCD group who eventually converted to dementia. The delayed recall of complex figure test (CFT_DR) identified fewer MCI patients (n=95) and misdiagnosed more preclinical AD patients (15.3%), in comparison with AVLT criterion. Criterion requiring deficits in both tests produced higher conversion rate (54.3%), but resulted in higher mis-diagnosis rate (14.7%) simultaneously. The AVLT criterion had the largest area under the curve (0.7248, p