Differences in the prognosis of gastric cancer patients of different sexes and races and the molecular mechanisms involved
Differences in the prognosis of gastric cancer patients of different sexes and races and the molecular mechanisms involved
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DOI：
10.3892/ijo.2019.4885
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发表时间：
2019-11-01
影响因子：
5.2
通讯作者：
Zhang, Changhua
中科院分区：
文献类型：
--
作者：
Li, Huafu;Wang, Chunming;Zhang, Changhua
为了评估胃癌患者性别和种族差异的预后和分子机制，我们使用了两个大型中心的数据，从性别和种族差异的角度对胃癌患者的生存进行了回顾分析。为了研究不同种族胃癌患者性别的分子机制，利用癌症基因组图谱数据库中的数据分析差异表达基因(Degs)，并进行基因本体论(GO)浓缩和DNA甲基化分析。在白人胃癌患者中，发现女性的生存预后好于男性；相反，在中国患者中，男性的预后好于男性。对于非裔美国人来说，性行为可能会对胃癌产生影响，但这种关系尚不清楚。不同性别间的核心基因包括白种人糖原蛋白2、假基因1、核糖体蛋白S4 Y连锁1、紫杉素-γ和真核细胞翻译起始因子1AX连锁，GO富集分析表明这些基因主要通过RNA结合和转录途径发挥作用。在黑人患者中，核心deg包括DNAJ热休克蛋白家族(Hsp40)成员C5、组蛋白脱乙酰酶10、新生素1和SMG5无义介导的mRNA衰变因子，根据GO浓缩分析，这些基因主要与细胞结构变化的途径有关。根据GO的说法，对于亚洲患者，核心degs包括锌指蛋白Y连接、胸腺素β4 Y连接、锌指蛋白787和参与细胞表面受体相关信号转导和G蛋白偶联受体蛋白信号通路的普遍转录的含有Y连接的四肽重复序列。不同核心基因的表达和通路的差异可能是影响不同种族和性别胃癌患者观察到的差异的主要原因。
To evaluate the prognostic and molecular mechanisms of sex and racial differences in gastric cancer, data from two large centers were used to retrospectively analyze the survival of gastric cancer patients with regard to sex and racial differences. In examining the molecular mechanism of sex in gastric cancer patients of different races, data from The Cancer Genome Atlas database were used to analyze differentially expressed genes (DEGs), and Gene Ontology (GO) enrichment and DNA methylation analyses were performed. Among White gastric cancer patients, it was found that the survival prognosis for females was better than that for males; conversely, among Chinese patients, males had a better prognosis. For African Americans, sex may have an impact on gastric cancer, but this relationship was unclear. The core DEGs between the different sexes included glycogenin 2 pseudogene 1, ribosomal protein S4 Y-linked 1, taxilin-gamma and eukaryotic translation initiation factor 1A X-linked among White patients, and GO enrichment analysis revealed that these genes act mainly through RNA binding and transcription pathways. Among Black patients, core DEGs included DnaJ heat shock protein family (Hsp40) member C5, histone deacetylase 10, neogenin 1 and SMG5 nonsense mediated mRNA decay factor, which are mainly related to pathways of cellular structural changes based on GO enrichment analysis. For Asian patients, core DEGs included zinc finger protein Y-linked, thymosin beta 4 Y-linked, zinc finger protein 787 and ubiquitously transcribed tetratricopeptide repeat containing, Y-linked, participating in cell surface receptor-associated signal transduction and G-protein coupled receptor protein signaling pathways, according to GO. The expression of different core genes and differences in path ways are likely to be the main causes affecting the variation observed among gastric cancer patients of different races and sexes.