Epidemiology of Moyamoya Disease in China: Single-Center, Population-Based Study
Epidemiology of Moyamoya Disease in China: Single-Center, Population-Based Study
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中国烟雾病流行病学：单中心、人群研究
DOI：
10.1016/j.wneu.2018.10.175
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发表时间：
2019-02-01
影响因子：
2
通讯作者：
Duan, Lian
中科院分区：
文献类型：
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作者：
Bao, Xiang-Yang;Wang, Qian-Nan;Duan, Lian
背景：据我们所知，还没有研究描述中国地区烟雾病的全国流行特征。我们描述了在中国单一机构治疗的MMD患者的流行病学特征，包括相对患病率、年龄分布、性别分布和最初的临床表现。结果：出现症状的中位年龄为30.36岁。MMD患者的年龄分布呈双峰分布，35~45岁为高峰，5~9岁为较小高峰。男女患者之比为1：1。本病以汉族为主，少数民族少见。在我们的队列中，短暂性脑缺血发作是最常见的首发临床表现(48.13%)。首发表现为脑梗塞(22.62%)、出血(16.45%)、头痛230/4128(5.57%)。在中国北部和东北部，缺血型较多，出血性较少。结论：本研究证实了中国等人的一些独特的流行病学特征，但也揭示了中国关于烟雾病的一些新的看法和趋势。由于缺乏全国性的流行病学研究，本研究初步勾勒出《中国》中的烟雾。
BACKGROUND: To our knowledge, no previous study has described the nationwide epidemiologic features of moyamoya disease (MMD) in China. We describe the epidemiologic features including the relative prevalence, age distribution, gender distribution, and initial clinical manifestations of patients with MMD treated at a single institution in China.METHODS: Our cohort included 4128 patients with MMD. Their demographic and clinical characteristics were obtained by retrospective chart review.RESULTS: The median age for the onset of symptoms was 30.36 years. The age distribution of patients with MMD was bimodal, with the highest peak detection rate at 35-45 years of age and a smaller peak at 5-9 years of age. The ratio of female-to-male patients was 1:1. The disease occurred mainly in the Han people and was rarely seen in minority nationalities. In our cohort, transient ischemic attack was the most common initial clinical manifestation (48.13%). The other initial manifestations included infarction (22.62%), hemorrhage (16.45%), and headache 230/4128 (5.57%). In north and northeast China, the ischemic type was more predominate while the hemorrhagic type was relatively rare. However, the percentage of hemorrhagic type in East China was higher than anywhere else in China.CONCLUSIONS: This study confirmed some unique epidemiologic features as the studies previously reported in China, but it also revealed some new sight and tendency about moyamoya in China. As a lack of national epidemiologic studies, this study indicated the outline of moyamoya in China.