The impaired development of innate lymphoid cells by preterm birth is associated with the infant disease
The impaired development of innate lymphoid cells by preterm birth is associated with the infant disease
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早产造成的先天淋巴细胞发育受损与婴儿疾病有关
DOI：
10.1016/j.scib.2020.09.012
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发表时间：
2021
期刊：
影响因子：
18.9
通讯作者：
Guo Xiaohuan
中科院分区：
文献类型：
--
作者：
Wang Wenyan;Xing Yan;Chang Yanmei;Wang Ying;You Yanxia;Chen Zekun;Ma Defu;Tong Xiaomei;Guo Xiaohuan
先天性淋巴细胞（ILC）是近几十年来新定义的免疫细胞，被认为是T辅助细胞的先天对应物，包括产生IFNc的1类ILC（ILC1s）、产生IL-5和IL-13的2类ILC（ILC2s）和产生IL-22的3类ILC（ILC3s）。虽然ILC的数量很少，但它们不仅是宿主维持组织所必需的免疫系统在生命早期尤其是早产时的形成至关重要。尽管早产儿免疫系统的发育已被广泛讨论[2]，但 ILC 的发育是否受到早产的影响仍不清楚。
Innate lymphoid cells(ILCs) are immune cells newly defined in recent decades and are recognized as the innate counterpart of the T helper cells, including IFNc-producing group 1 ILCs(ILC1s), IL-5 and IL-13-producing group 2 ILCs(ILC2s), and IL-22-producing group 3 ILCs(ILC3s).Although with a tiny population, ILCs are not only required for the host to maintain the tissue homeostasis and defense against pathogen invasion but also actively involved in various inflammatory and allergic diseases [1].The immune system is shaped critically in early life, especially when born preterm.Although the development of the immune system in preterm children has been extensively discussed [2], it is still unknown whether the development of ILCs is influenced by preterm birth.