Dopamine-dependent synaptic plasticity in an amygdala inhibitory circuit controls fear memory expression.
Dopamine-dependent synaptic plasticity in an amygdala inhibitory circuit controls fear memory expression.
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DOI：
10.1016/j.neuron.2015.09.001
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发表时间：
2016-01
期刊：
影响因子：
3.8
通讯作者：
Kim JH
中科院分区：
文献类型：
--
作者：
Lee JH;Kim JH
在日常生活中发生的众多事件中，我们很容易记住重要的信息，但不会长时间保留大多数不太重要的事件。虽然有些情节包含了纯粹的情感方面，但显着性较低的信息很少通过未知的机制存储在神经回路中。我们提供的大量证据表明，杏仁核背侧ITC的突触可塑性允许选择性存储突出的情感体验，而它阻止不太突出的经验进入长期记忆。在激活D4 R或弱恐惧条件反射后，STDP刺激诱导LA-ITC突触中的LTD。这种形式的LTD依赖于突触前D4 R，并且可能是由于GABA释放的增强。LTD的光遗传学废除和体内背侧ITC处的D4 R的消融两者都导致增强的和过度普遍化的恐惧反应。最后，我们证明了LTD在PTSD模型小鼠的背侧ITC受损，这表明GABA能信号的适应不良和由此产生的LTD损伤有助于PTSD的内表型。[BMB报告2016; 49（1）：1-2]
Of the numerous events that occur in daily life, we readily remember salient information, but do not retain most less-salient events for a prolonged period. Although some of the episodes contain putatively emotional aspects, the information with lower saliency is rarely stored in neural circuits via an unknown mechanism. We provided substantial evidence indicating that synaptic plasticity in the dorsal ITC of amygdala allows for selective storage of salient emotional experiences, while it deters less-salient experience from entering long-term memory. After activation of D4R or weak fear conditioning, STDP stimulation induces LTD in the LA-ITC synapses. This form of LTD is dependent upon presynaptic D4R, and is likely to result from enhancement of GABA release. Both optogenetic abrogation of LTD and ablation of D4R at the dorsal ITC in vivo lead to heightened and over-generalized fear responses. Finally, we demonstrated that LTD was impaired at the dorsal ITC of PTSD model mice, which suggests that maladaptation of GABAergic signaling and the resultant LTD impairment contribute to the endophenotypes of PTSD. [BMB Reports 2016; 49(1): 1-2]