Genomic Insights Into the Multiple Factors Controlling Abdominal Fat Deposition in a Chicken Model.
Genomic Insights Into the Multiple Factors Controlling Abdominal Fat Deposition in a Chicken Model.
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DOI：
10.3389/fgene.2018.00262
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发表时间：
2018
影响因子：
3.7
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Abdalla BA;Chen J;Nie Q;Zhang X
肉鸡生长速度提高的遗传选择一直伴随着过量的脂肪积累，特别是在腹腔。这些进展到间接的，往往是不健康的影响肉类品质和饲料成本的增加。近年来，基因组学技术的进步带来了令人惊讶的发现，基因组比以前认为的要复杂得多。研究已经确定了与腹部脂肪沉积有关的多种遗传因素。与此同时，肥胖的流行已将注意力集中在脂肪组织和脂肪细胞的发育上。本文综述了目前对与鸡腹部脂肪沉积或前脂肪细胞增殖和分化相关的遗传/表观遗传因素的理解。本文讨论的结果已经通过不同的基因组方法确定，如基于qtl的研究、候选基因方法、上位性相互作用、拷贝数变异、单核苷酸多态性筛选、选择特征分析、全基因组关联研究、RNA测序和亚硫酸盐测序。本综述中提到的研究描述了涉及腹部脂肪沉积的多种遗传因素。因此，进一步深入研究多遗传因素，开发新的分子标记或潜在靶点，将为减少肉型鸡腹部脂肪沉积提供有前景的应用。
Genetic selection for an increased growth rate in meat-type chickens has been accompanied by excessive fat accumulation particularly in abdominal cavity. These progressed to indirect and often unhealthy effects on meat quality properties and increased feed cost. Advances in genomics technology over recent years have led to the surprising discoveries that the genome is more complex than previously thought. Studies have identified multiple-genetic factors associated with abdominal fat deposition. Meanwhile, the obesity epidemic has focused attention on adipose tissue and the development of adipocytes. The aim of this review is to summarize the current understanding of genetic/epigenetic factors associated with abdominal fat deposition, or as it relates to the proliferation and differentiation of preadipocytes in chicken. The results discussed here have been identified by different genomic approaches, such as QTL-based studies, the candidate gene approach, epistatic interaction, copy number variation, single-nucleotide polymorphism screening, selection signature analysis, genome-wide association studies, RNA sequencing, and bisulfite sequencing. The studies mentioned in this review have described multiple-genetic factors involved in an abdominal fat deposition. Therefore, it is inevitable to further study the multiple-genetic factors in-depth to develop novel molecular markers or potential targets, which will provide promising applications for reducing abdominal fat deposition in meat-type chicken.