Feeding enriched omega-3 fatty acid beef to rats increases omega-3 fatty acid content of heart and liver membranes and decreases serum vascular cell adhesion molecule-1 and cholesterol levels
Feeding enriched omega-3 fatty acid beef to rats increases omega-3 fatty acid content of heart and liver membranes and decreases serum vascular cell adhesion molecule-1 and cholesterol levels
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DOI：
10.1016/j.nutres.2007.04.003
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发表时间：
2007-05-01
影响因子：
4.5
通讯作者：
Drouillard, James S.
中科院分区：
文献类型：
--
作者：
Medeiros, Denis M.;Hampton, Meghan;Drouillard, James S.
饮食中摄入长链欧米茄-3脂肪酸可以预防心脏病的发生。在这项研究中，我们评估了从富含omega-3脂肪酸的饮食中喂养牛的牛肉对大鼠是否有健康益处。与饲喂玉米对照饮食的牛相比，饲喂10%亚麻籽饮食的牛在肌肉组织中含有大量的α-亚麻酸。给20只刚断奶的Sprague-Dawley大鼠喂食两种饮食中的一种（每组n = 10），一种饮食含有来自饲喂10%亚麻籽的牛的牛肉的脂肪，另一种饮食来自饲喂常规混合饲料的牛的牛肉。饮食中含有10%的脂肪来自熟牛肉，使用1976年制定的美国营养学会饮食的修改，为期5周。有一个统计学上的显着增加，在膜二十二碳六烯酸的量在大鼠的肝脏上的饮食牛肉从牛喂养亚麻籽和一个统计学上显着增加，在膜花生四烯酸的量在心脏的控制。也有强烈的，积极的趋势增加的数额膜二十二碳六烯酸在心脏和膜亚油酸在肝脏的大鼠的饮食牛肉从牛饲养亚麻籽相比，控制。血清胆固醇和血管细胞粘附分子-1水平降低大鼠喂养的牛肉从牛喂养亚麻籽。这些发现表明，向牛饲喂高ω-3脂肪酸饮食的农业实践可以对消费者产生积极的健康益处。(C)2007年爱思唯尔公司All rights reserved.
Dietary intake of the long-chain omega-3 fatty acids prevents the development of heart disease. In this study, we evaluated whether feeding beef from cattle fed an omega-3 fatty acid-enriched diet to rats had health benefits. Cattle raised on a 10% flaxseed diet have high amounts of alpha-linolenic acid in their muscle tissue when compared to cattle fed a control diet of corn. Twenty, weanling, Sprague-Dawley rats were fed one of two diets (n = 10 in each group), one diet containing fat from beef of cattle fed 10% flaxseed and the other beef from cattle fed a conventional com ration. The diets contained 10% fat from the cooked beef using a modification of the American Institute of Nutrition diet formulated in 1976 diet for a 5-week period. There was a statistically significant increase in the amount of membrane docosahexaenoic acid in the livers of the rats on the diet of beef from cattle fed flaxseed and a statistically significant increase in the amount of membrane arachidonic acid in the hearts of the controls. There were also strong, positive trends for the increases in the amounts of membrane docosahexaenoic acid in the hearts and membrane linoleic acid in the livers of the rats on the diet of beef from cattle fed flaxseed when compared with controls. Serum cholesterol and vascular cell adhesion molecule-1 levels were decreased in rats fed the beef from cattle fed flaxseed. These findings suggest that agriculture practice of feeding a high omega-3 fatty acid diet to cattle can produce positive health benefits to the consumer. (C) 2007 Elsevier Inc. All rights reserved.