Type 1 Diabetes: Current Concepts in Epidemiology, Pathophysiology, Clinical Care, and Research
Type 1 Diabetes: Current Concepts in Epidemiology, Pathophysiology, Clinical Care, and Research
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DOI：
10.1016/j.cppeds.2012.07.002
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发表时间：
2012-11-01
影响因子：
1.6
通讯作者：
Haller, Michael J.
中科院分区：
文献类型：
--
作者：
Gan, Mary Joyce;Albanese-O'Neill, Anastasia;Haller, Michael J.
1型糖尿病（T1D）是一种自身免疫性疾病，由遗传和环境因素共同介导，导致胰岛淋巴细胞浸润、β细胞破坏和终生依赖外源性胰岛素。虽然T1D很普遍（1 / 300），并且其发病率在世界范围内稳步增长（每年3%），但导致该疾病的确切基因-环境相互作用仍不清楚。对于患者、家属和护理人员来说，与T1D生活在一起是一项挑战。由于儿科内分泌专家的相对缺乏，普通儿科医生和其他专科医生可能偶尔会面临处理糖尿病相关投诉的任务。在此，我们提供了一个全面的回顾自然历史，病理生理学，和当代管理的T1D。此外，还讨论了T1D的最新研究进展。2012年儿科青少年保健；42:269 - 291
Type 1 diabetes (T1D) is an autoimmune disease mediated by a combination of genetic and environmental triggers resulting in lymphocytic infiltration of pancreatic islets, destruction of beta cells, and lifelong dependency on exogenous insulin. Although T1D is prevalent (1 in 300) and its incidence is steadily increasing worldwide (3% per year), the exact gene-environment interactions precipitating the disease remain unknown. Living with T1D is challenging for patients, families, and caregivers. Because of the relative paucity of pediatric endocrinologists, general pediatricians and other subspecialists may occasionally be faced with the task of managing diabetes-related complaints. Herein, we provide a comprehensive review of the natural history, pathophysiology, and contemporary management of T1D. In addition, recent advances in T1D research are discussed. Curr Probl Pediatr Adolesc Health Care 2012;42:269-291