Diabetes is associated with worse executive function in both eastern and western populations: Shanghai aging study and mayo clinic study of aging
Diabetes is associated with worse executive function in both eastern and western populations: Shanghai aging study and mayo clinic study of aging
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DOI：
10.1016/j.jalz.2015.06.801
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发表时间：
2015-07
期刊：
影响因子：
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通讯作者：
Qianhua Zhao
中科院分区：
文献类型：
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作者：
Qianhua Zhao
糖尿病（DM）与认知功能之间的关系在东西方人群中是否存在差异，目前尚不清楚。本研究旨在阐明糖尿病是否与较差的认知性能在这两个population.MethodsThe上海老龄化研究（SAS）和马约诊所老龄化研究（MCSA）是两个人口为基础的研究，在上海，中国和罗切斯特，美国明尼苏达州具有相似的设计和方法。非痴呆的参与者接受认知测试，并从医疗记录中评估DM。在SAS和MCSA进行单独的分析，DM和认知performance.ResultsA共3348中国参与者在SAS和3734美国的MCSA科目之间的关联。与MCSA受试者相比，SAS受试者更年轻，受教育程度更低，血管疾病，APOE ε4携带者和肥胖的频率更低。DM参与者（与非DM参与者相比）在SAS和MCSA的所有认知领域都表现得更差。校正年龄、性别、教育程度和血管协变量后，在总样本和认知正常子样本中，DM与执行功能表现较差相关（SAS的β=-0.15，p= 0.001，MCSA的β=-0.10，p= 0.008）。此外，糖尿病与SAS中的视觉空间技能，语言和记忆力表现不佳相关，但在MCSA.ConclusionsDiabetes与认知功能障碍相关，特别是对执行功能产生负面影响，无论种族，年龄和血管危险因素的患病率如何。
BackgroundIt remains unknown whether the association between diabetes mellitus (DM) and cognitive function differs in Eastern and Western populations. This study aimed to elucidate whether DM is associated with worse cognitive performance in both populations.MethodsThe Shanghai Aging Study (SAS) and the Mayo Clinic Study of Aging (MCSA) are two population-based studies with similar design and methodology in Shanghai, China and Rochester, MN USA. Non-demented participants underwent cognitive testing, and DM was assessed from the medical record. Separate analyses were performed in SAS and MCSA regarding the association between DM and cognitive performance.ResultsA total of 3348 Chinese participants in the SAS and 3734 American subjects in the MCSA were included. Compared with MCSA subjects, SAS participants were younger, less educated, and had lower frequency of vascular disease, APOE ε4 carriers and obesity. Participants with DM (compared to non-DM participants) performed significantly worse on all the cognitive domains in both the SAS and MCSA. After adjustment for age, sex and education, and vascular covariates, DM was associated with worse performance in executive function (β=-0.15, p= 0.001 for SAS, and β=-0.10, p= 0.008 for MCSA) in the total sample and in the cognitively normal sub-sample. Furthermore, DM was associated with poor performance in visuospatial skills, language, and memory in the SAS, but not in the MCSA.ConclusionsDiabetes is associated with cognitive dysfunction, in particular exerts a negative impact on executive function regardless of race, age and prevalence of vascular risk factors.