Hyperpolarized Helium-3 Diffusion-weighted Magnetic Resonance Imaging Detects Abnormalities of Lung Structure in Children With Bronchopulmonary Dysplasia
Hyperpolarized Helium-3 Diffusion-weighted Magnetic Resonance Imaging Detects Abnormalities of Lung Structure in Children With Bronchopulmonary Dysplasia
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DOI：
10.1097/rti.0000000000000244
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发表时间：
2017-09-01
影响因子：
3.3
通讯作者：
Altes, Talissa A.
中科院分区：
文献类型：
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作者：
Flors, Lucia;Mugler, John P., III;Altes, Talissa A.
目的：本研究的目的是确定是否超极化3 He扩散加权磁共振成像检测异常的儿童支气管肺发育不良（BPD）与年龄匹配的正常children.Materials和Methods：所有实验均符合健康保险携带和责任法案（HIPAA）和食品和药物管理局批准的IND申请下进行。该方案得到了我们的机构审查委员会的批准，并获得了书面知情同意书。对16例有早产合并BPD病史的受试者进行了超极化He-3弥散加权磁共振成像（年龄范围，6.8 - 13.5岁;平均9.0岁）和29例健康足月分娩受试者年龄4.5-14.7岁;平均9.2 y），采用梯度回波序列，双极扩散梯度，测量2个B值（0和1.6 s/cm（2））。采用普通最小二乘多元回归法对两组之间的全肺平均表观扩散系数（ADC）、第90百分位数ADC以及ADC > 0.2 cm（2）/s的全肺体积百分比进行年龄相关比较。结果：BPD受试者的平均ADC明显更大（0.187 vs. 0.152 cm（2）/s，P < 0.001）。BPD组的第90百分位ADC和ADC > 0.2 cm（2）/s的平均肺容积百分比也较高（0.258 vs. 0.215 cm（2）/s，30.3% vs. 11.9%，P < 0.001）。两组的体表面积调整通气肺容量相似（1.93 vs. 1.91L，P = 0.90）。结论：与年龄匹配的健康受试者相比，BPD儿童具有较高的ADC和相同的肺容量，这表明BPD儿童的肺泡扩大，数量减少。
Purpose: The aim of the study was to determine whether hyperpolarized 3He diffusion-weighted magnetic resonance imaging detects abnormalities in the lungs in children with bronchopulmonary dysplasia (BPD) as compared with age-matched normal children.Materials and Methods: All experiments were compliant with Health Insurance Portability and Accountability Act (HIPAA) and performed with Food and Drug Administration approval under an IND application. The protocol was approved by our Institutional Review Board, and written informed consent was obtained. Hyperpolarized He-3 diffusion-weighted magnetic resonance imaging was performed in 16 subjects with a history of preterm birth complicated by BPD (age range, 6.8 to 13.5 y; mean, 9.0 y) and in 29 healthy term-birth subjects (age range, 4.5-14.7 y; mean, 9.2 y) using a gradient-echo sequence with bipolar diffusion gradients and with measurements at 2 b values (0 and 1.6 s/cm(2)). Age-related comparison of the whole-lung mean apparent diffusion coefficient (ADC), 90th percentile ADC, and percentage of whole-lung volume with ADC > 0.2 cm(2)/s between the 2 groups was examined using ordinary least-squares multiple regression.Results: The mean ADC was significantly greater in subjects with BPD (0.187 vs. 0.152 cm(2)/s, P < 0.001). The 90th percentile ADC and mean percentage lung volume with ADC > 0.2 cm(2)/s were also higher in the BPD group (0.258 vs. 0.215 cm(2)/s, 30.3% vs. 11.9%, P < 0.001 for both). The body surface area-adjusted ventilated lung volume was similar in the 2 groups (1.93 vs. 1.91L, P = 0.90).Conclusions: Children with BPD had higher ADCs and the same lung volumes when compared with age-matched healthy subjects, suggesting that children with BPD have enlarged alveoli that are reduced in number.