CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer.
CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer.
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DOI：
10.1186/s12885-023-10882-7
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发表时间：
2023-05-19
期刊：
影响因子：
3.8
通讯作者：
Cao, Hui
中科院分区：
文献类型：
--
作者：
Xu, Danhua;Liu, Xu;Ke, Shouyu;Guo, Yixian;Zhu, Chunchao;Cao, Hui
胃癌在世界范围内具有很高的发病率和死亡率。阻断程序性细胞死亡蛋白1通路已被批准用于多种肿瘤的治疗，并取得了显著的临床治疗效果。然而，免疫检查点抑制剂在胃癌治疗中未能取得令人满意的效果。有必要确定新的免疫治疗靶点胃癌。我们分析了胃癌样本中Treg细胞和CD8 + T细胞的相关性。我们研究趋化因子与胃癌组织中Treg细胞或CD8 + T细胞的关系。我们比较TCGA数据库中胃癌患者CCL19/CCR7的表达。我们通过transwell实验来确定CCL19对Treg细胞和CD8 + T细胞迁移能力的影响。我们在胃癌数据库中对CCL19和CCR7进行了生存分析。胃癌组织中Treg细胞与CD8 + T细胞呈正相关。Treg细胞在肿瘤组织中的表达明显上调。FOXP3高表达患者的总生存率低于FOXP3低表达患者。CCL19与FOXP3相关性强，与CD8A相关性弱。CCL19对Treg细胞的迁移能力有较强的影响，对CD8 + T细胞的迁移能力影响较弱。CCL19和CCR7在胃癌组织中的表达均显著上调。生存分析表明，CCL19和CCR7均提示胃癌预后不良。CCL19/CCR7可能是胃癌潜在的新治疗靶点。
Gastric cancer is associated with significant morbidity and mortality in the world. Blocking programmed cell death protein 1 pathway have been approved for the treatment of a variety of tumors and have achieved remarkable clinical therapeutic effects. However, immune checkpoint inhibitors failed to achieve satisfactory results in gastric cancer. There is a need to identify novel immunotherapy targets in gastric cancer. We analysed the correlation between Treg cells and CD8 + T cells in gastric cancer samples. We studied the relationship between chemokines and Treg cells or CD8 + T cells in gastric cancer. We compared CCL19/CCR7 expression in gastric cancer patients in TCGA database. We performed transwell experiments to determine the influence of CCL19 on Treg cells and CD8 + T cells migratory capacity. We conducted survival analysis of CCL19 and CCR7 in gastric cancer database. Treg cells show positive correlation with CD8 + T cells in gastric cancer. Treg cell expression was significantly upregulated in tumor tissues. Patients with high FOXP3 expression had worse overall survival than those with low FOXP3 expression. CCL19 had strong correlation with FOXP3 and weak correlation with CD8A. CCL19 had strong impact on the migratory capacity of Treg cells but weak impact on the migratory capacity of CD8 + T cells. Both CCL19 and CCR7 expression were significantly upregulated in gastric cancer tissues. Survival analysis demonstrated that both CCL19 and CCR7 indicate poor prognosis in gastric cancer. CCL19/CCR7 may be a potential novel therapeutic target in gastric cancer.
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DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
影响因子：
32.4
作者：
Joshi NS;Akama-Garren EH;Lu Y;Lee DY;Chang GP;Li A;DuPage M;Tammela T;Kerper NR;Farago AF;Robbins R;Crowley DM;Bronson RT;Jacks T
通讯作者：
Jacks T
影响因子：
2.5
作者：
Migita, Kazuhiro;Matsumoto, Sohei;Kanehiro, Hiromichi
通讯作者：
Kanehiro, Hiromichi
影响因子：
9.2
作者：
Malet-Engra, Gema;Yu, Weimiao;Dupre, Loic
通讯作者：
Dupre, Loic
DOI：
10.1001/jama.2016.20324
发表时间：
2017-01-24
期刊：
JAMA
影响因子：
--
作者：
Mokdad AH;Dwyer-Lindgren L;Fitzmaurice C;Stubbs RW;Bertozzi-Villa A;Morozoff C;Charara R;Allen C;Naghavi M;Murray CJ
通讯作者：
Murray CJ