The Muller cell: A functional element of the retina
The Muller cell: A functional element of the retina
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DOI：
10.1016/0166-2236(96)10040-0
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发表时间：
1996-08-01
影响因子：
15.9
通讯作者：
Reichenbach, A
中科院分区：
文献类型：
--
作者：
Newman, E;Reichenbach, A
Muller 细胞是视网膜的主要神经胶质细胞，承担着其他中枢神经系统区域的星形胶质细胞、少突胶质细胞和室管膜细胞所执行的许多功能。 Muller 细胞表达大量电压门控通道和神经递质受体，可识别各种神经元信号并触发细胞去极化和细胞内 Ca2+ 波。反过来，Muller 细胞通过调节神经活性物质的细胞外浓度来调节神经元活动，包括： (1) K+，通过 Muller 细胞空间缓冲电流传输； (2)谷氨酸和GABA，被Muller细胞高亲和力载体摄取； (3) H+，其受穆勒细胞Na+-HCO3-共转运和碳酸酐酶的作用控制。 Muller 细胞和视网膜神经元之间的双向通讯表明 Muller 细胞在视网膜功能中发挥着积极作用。
Muller cells are the principal glial cells of the retina, assuming many of the functions carried out by astrocytes, oligodendrocytes and ependymal cells in other CNS regions. Muller cells express numerous voltage-gated channels and neurotransmitter receptors, which recognize a variety of neuronal signals and trigger cell depolarization and intracellular Ca2+ waves. In turn, Muller cells modulate neuronal activity by regulating the extracellular concentration of neuroactive substances, including: (1) K+, which is transported via Muller-cell spatial-buffering currents; (2) glutamate and GABA, which are taken up by Muller-cell high-affinity carriers; and (3) H+, which is controlled by the action of Muller-cell Na+-HCO3- co-transport and carbonic anhydrase. The two-way communication between Muller cells and retinal neurons indicates that Muller cells play an active role in retinal function.