The relationship between high-density lipoprotein cholesterol levels and arterial stiffness in a Taiwanese population.
The relationship between high-density lipoprotein cholesterol levels and arterial stiffness in a Taiwanese population.
复制标题
台湾人群高密度脂蛋白胆固醇水平与动脉僵硬度之间的关系。
DOI：
10.1016/j.numecd.2017.10.003
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
C
中科院分区：
文献类型：
--
作者：
W;F. Lu;Y;J;Y.;Y;C
背景和目的目前关于高密度脂蛋白胆固醇（HDL-C）水平与动脉硬化（AS）之间关系的研究很少。HDL-C水平在男性和女性中存在差异，目前尚不清楚HDL-C水平与AS之间的关系是否受性别影响。本研究的目的是探讨性别差异之间的关联HDL-C水平和AS在adult.Methods和ResultsAfter排除受试者使用降脂剂，7254名受试者参加。通过测量臂踝脉搏波传导速度（baPWV）值评估AS。HDL-C的四分位数在男性中分别为<38、38-45、45-53和>53 mg/dL，在女性中分别为<48、48-57、57-69和>68 mg/dL。在年龄<50岁的受试者中，HDL-C四分位数均与baPWV值无关。在年龄≥50岁的受试者中，HDL-C的最高四分位数（β：−37.57，95% CI：−61.61至−13.54）与baPWV值呈负相关。当考虑年龄≥50岁受试者的性别差异时，HDL-C的最高四分位数（Q4 beta：−57.22，95% CI：-95.63至-18.81）与女性baPWV值呈负相关，但HDL-C四分位数与男性baPWV值无关。在年龄≥50岁的女性中，C水平与AS风险降低相关，但在男性中则无关，尽管这种关系在年龄<50岁的受试者中并不明显。因此，在年龄≥50岁的人群中，HDL-C水平与AS之间的相关性受到性别的影响。
Background and aimsThere are few studies on the association between HDL-C levels and arterial stiffness (AS). HDL-C levels vary in males and females, and it is not clear whether the relationship between HDL-C levels and AS is influenced by gender. The purpose of this study was to investigate gender differences in the association between HDL-C levels and AS in adults.Methods and ResultsAfter excluding subjects using lipid-lowering agent, 7254 subjects were enrolled. The AS was assessed by measuring the brachial-ankle pulse wave velocity (baPWV) value. The quartiles of HDL-C were <38, 38–45, 45–53 and >53 mg/dL in men and <48, 48–57, 57–69 and >68 mg/dL in women, respectively. In subjects aged <50 years, none of the HDL-C quartiles were associated with baPWV values. In subjects aged ≥50 years, the highest quartile of HDL-C (beta: −37.57, 95% CI: −61.61 to −13.54) was negatively related to baPWV values. When considering gender difference in subjects aged ≥50 years, the highest quartile of HDL-C (Q4 beta: −57.22, 95% CI: −95.63 to −18.81) was inversely associated with baPWV values in women, but none of the HDL-C quartiles were related to baPWV values in men.ConclusionsA high HDL-C level was associated with a lower risk of AS in subjects aged ≥50 years in women but not in men, although this relationship was not apparent in subjects aged <50 years. The association between HDL-C level and AS is thus influenced by gender in people aged ≥50 years.
影响因子：
5
作者：
Ahmed, Haitham M.;Miller, Michael;Blaha, Michael J.
通讯作者：
Blaha, Michael J.