AIDS Therapy Evaluation in the Netherlands (ATHENA) national observational HIV cohort: cohort profile.
AIDS Therapy Evaluation in the Netherlands (ATHENA) national observational HIV cohort: cohort profile.
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DOI：
10.1136/bmjopen-2018-022516
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发表时间：
2018-09-24
期刊：
影响因子：
2.9
通讯作者：
ATHENA national observational HIV cohort
中科院分区：
文献类型：
--
作者：
Boender TS;Smit C;Sighem AV;Bezemer D;Ester CJ;Zaheri S;Wit FWNM;Reiss P;ATHENA national observational HIV cohort
1998年，设立了荷兰艾滋病治疗评价国家艾滋病毒观察性队列，以证明最近可供临床使用的三联抗逆转录病毒疗法，包括艾滋病毒蛋白酶抑制剂的救命效力。随后，荷兰卫生、福利和体育部设立了艾滋病毒监测基金会，继续将ATHENA作为一个开放队列，以便继续登记和监测所有艾滋病毒阳性者，作为荷兰所有26个艾滋病毒治疗中心艾滋病毒护理的一个组成部分。到目前为止，共有25036名参与者入组该队列，随访263600人年。截至2017年1月1日，已知有19，035名HIV-1阳性参与者接受护理：18，824名成年人（81%男性和19%女性）和211名儿童（47%男孩和53%女孩）。其余6001名参与者要么死亡（46%），要么失去护理（29%），要么移居国外（25%）。今天，经过20多年的随访，ATHENA队列提供了关于艾滋病毒治疗、合并症和合并感染的广泛知识，并深入了解了艾滋病毒流行病的传播动态。ATHENA继续在荷兰登记和监测接受艾滋病毒护理的艾滋病毒阳性者。今后的研究将继续为荷兰和国际上的艾滋病毒护理和预防政策提供切实的投入。
In 1998, the AIDS Therapy Evaluation in the Netherlands (ATHENA) national observational HIV cohort was established to demonstrate the lifesaving effectiveness of triple combination antiretroviral therapy, including HIV-protease inhibitors, that had recently been made available for clinical use. Subsequently, the HIV Monitoring Foundation was established by the Dutch Ministry of Health, Welfare and Sport to continue ATHENA as an open cohort in order to continue the registration and monitoring of all HIV-positive people as an integral part of HIV care in all 26 HIV treatment centres in the Netherlands. To date, a total of 25 036 participants have been enrolled in the cohort, with 263 600 person-years of follow-up. As of 1 January 2017, 19 035 HIV-1-positive participants were known to be in care: 18 824 adults (81% men and 19% women) and 211 children (47% boys and 53% girls). The remaining 6001 participants had either died (46%), were lost to care (29%) or had moved abroad (25%). Today, with over 20 years of follow-up, the ATHENA cohort has provided extensive knowledge on HIV treatment, comorbidities and coinfections and created insight into the transmission dynamics of the HIV epidemic. ATHENA continues to enrol and monitor HIV positive people entering HIV care in the Netherlands. Future research will continue to provide tangible input into HIV care and prevention policies in the Netherlands and internationally.
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DOI：
10.2174/1874613601004010096
发表时间：
2010-05-05
期刊：
The open AIDS journal
影响因子：
--
作者：
Hillebregt M;de Lange-de Klerk E;Knol D;de Wolf F;Smit C
通讯作者：
Smit C
影响因子：
11.8
作者：
Boerekamps, Anne;Newsum, Astrid M.;van der Valk, Marc
通讯作者：
van der Valk, Marc
影响因子：
3.8
作者：
Jansen, Iralice A. V.;Geskus, Ronald B.;Stolte, Ineke G.
通讯作者：
Stolte, Ineke G.
影响因子：
11.8
作者：
Benard, Antoine;van Sighem, Ard;Matheron, Sophie
通讯作者：
Matheron, Sophie
影响因子：
3.8
作者：
Bezemer, Daniela;de Wolf, Frank;Fraser, Christophe
通讯作者：
Fraser, Christophe