Inhibition of Apoptosis and Efficacy of Pan Caspase Inhibitor, Q-VD-OPh, in Models of Human Disease.
Inhibition of Apoptosis and Efficacy of Pan Caspase Inhibitor, Q-VD-OPh, in Models of Human Disease.
复制标题
人类疾病模型中PAN caspase抑制剂Q-VD-OPH的凋亡和功效的抑制作用。
DOI：
10.4137/jcd.s23844
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Brown TL
中科院分区：
文献类型：
--
作者：
Keoni CL;Brown TL
细胞凋亡是维持细胞稳态所需的生理细胞死亡，而半胱天冬酶在这一过程中起着重要作用。当机体内的细胞凋亡水平过高时，会发生许多疾病，一些研究已经探索了使用caspase抑制剂来预防这些疾病的可能性。Q-VD-OPh （quinolyl-valyl- o -methyl laspartyl-[2,6-二氟苯氧基]-methyl酮）是一种新型的泛半胱天冬酶抑制剂，由于其在低浓度下抑制细胞凋亡的效果，能够穿过血脑屏障，并且在体内无毒而被使用。本文综述了Q-VD-OPh在几种人类疾病动物模型中抑制细胞凋亡的能力。
Apoptosis is physiological cell death required for the cellular maintenance of homeostasis, and caspases play a major role in the execution of this process. Numerous disorders occur when levels of apoptosis within an organism are excessive, and several studies have explored the possibility of using caspase inhibitors to prevent these disorders. Q-VD-OPh (quinolyl-valyl-O-methylaspartyl-[2,6-difluorophenoxy]-methyl ketone), a novel pan caspase inhibitor, has been used because of its efficacy to inhibit apoptosis at low concentrations, its ability to cross the blood–brain barrier, as well as being nontoxic in vivo. This review examines Q-VD-OPh’s ability to inhibit apoptosis in several animal models of human disease.