Parallel input channels to mouse primary visual cortex.
Parallel input channels to mouse primary visual cortex.
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DOI：
10.1523/jneurosci.6456-09.2010
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发表时间：
2010-04-28
期刊：
影响因子：
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通讯作者：
Burkhalter A
中科院分区：
文献类型：
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作者：
Gao E;DeAngelis GC;Burkhalter A
人们普遍认为，在哺乳动物中，视觉信息是沿着沿着功能专门化的平行通路发送到大脑的，但小鼠视觉系统是否使用类似的处理策略尚不清楚。解决这个问题很重要，因为小鼠大脑提供了一个易于处理的系统，用于开发影响时空视觉处理的疾病的细胞和分子理解。我们在小鼠初级视觉皮层中使用单个单位记录来研究单个神经元是否对一组感觉线索比另一组更敏感。定量分析表明，短反应潜伏期神经元的空间视敏度低，对对比度、时间频率和速度的敏感性高，而长反应潜伏期神经元的空间视敏度高，对对比度、时间频率和速度的敏感性低。这些相关性表明，在小鼠V1神经元接收输入的加权组合的平行传入通路具有不同的时空敏感性。
It is generally accepted that in mammals visual information is sent to the brain along functionally specialized parallel pathways, but whether the mouse visual system uses similar processing strategies is not known. It is important to resolve this issue because the mouse brain provides a tractable system for developing a cellular and molecular understanding of disorders affecting spatiotemporal visual processing. We have used single unit recordings in mouse primary visual cortex to study whether individual neurons are more sensitive to one set of sensory cues than another. Our quantitative analyses show that neurons with short response latencies have low spatial acuity and high sensitivity to contrast, temporal frequency and speed, whereas neurons with long latencies have high spatial acuity, low sensitivities to contrast, temporal frequency and speed. These correlations suggest that neurons in mouse V1 receive inputs from a weighted combination of parallel afferent pathways with distinct spatiotemporal sensitivities.