Noninvasive optical Imaging in the visual cortex in young infants
Noninvasive optical Imaging in the visual cortex in young infants
复制标题
DOI：
10.1002/hbm.20020
复制
发表时间：
2004-06-01
影响因子：
4.8
通讯作者：
Itoh, S
中科院分区：
文献类型：
--
作者：
Kusaka, T;Kawada, K;Itoh, S
在发育阶段，大脑经历解剖，功能和代谢变化，以支持成熟个体的复杂适应行为。对大脑不同区域发生的发育变化的估计将提供一种将各种行为现象与成熟特异性大脑结构联系起来的方法，从而提供关于正常和疾病状态下结构-功能关系的有用信息。我们使用多通道近红外光谱（MNIRS），一种新的非侵入性成像技术，用于揭示选定大脑区域的神经活动过程，以监测视觉皮层的活动，反映了婴儿在自然睡眠期间接受光刺激的血流动力学反应。在婴儿中，光刺激导致视觉皮层中的氧合血红蛋白和总血红蛋白减少，脱氧血红蛋白增加。这种反应模式不同于以前报道的成人反应模式。婴儿和成人视皮层对光刺激反应的不同模式可能反映了发育和行为的差异。它可能反映了婴儿视觉皮层的不同功能组织或正在进行的视网膜发育。我们的结果表明，局部血流动力学的变化可以检测到周围的视觉皮层的一个小区域。MNIRS为研究和非侵入性临床应用提供了相当大的潜力。(C)2004 Wiley-Liss，Inc.
During the developmental stage, the brain undergoes anatomic, functional, and metabolic changes necessary to support the complex adaptive behavior of a mature individual. Estimation of developmental changes occurring in different regions of the brain would provide a means of relating various behavioral phenomena to maturation-specific brain structures, thereby providing useful information on structure-function relationships in both normal and disease states. We used multichannel near-infrared spectroscopy (MNIRS), a new noninvasive imaging technique for revealing the course of neural activity in selected brain regions, to monitor the activities of the visual cortex as mirrored by hemodynamic responses in infants subjected to photostimulation during natural sleep. In the infants, oxyhemoglobin and total hemoglobin decreased and deoxyhemoglobin increased in the visual cortex with photostimulation. This pattern of responses was different from the response pattern in adults reported previously. The different patterns of responses to photostimulation in the visual cortices of infants and adults might reflect developmental and behavioral differences. It may reflect a different functional organization of the visual cortex in infants or ongoing retinal development. Our results demonstrated that regional hemodynamic change could be detected in a small area around the visual cortex. MNIRS offers considerable potential for research and noninvasive clinical applications. (C) 2004 Wiley-Liss, Inc.