Sensitivity of salivary glands to radiation: from animal models to therapies.

Sensitivity of salivary glands to radiation: from animal models to therapies.
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DOI:
10.1177/0022034509343143
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发表时间:
2009-10
影响因子:
7.6
通讯作者:
Limesand KH
Limesand KH
中科院分区:
医学1区
文献类型:
--
作者:
Grundmann O;Mitchell GC;Limesand KH

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Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.
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