Lipoprotein lipase activity and gene expression in lung cancer and in adjacent noncancer lung tissue
Lipoprotein lipase activity and gene expression in lung cancer and in adjacent noncancer lung tissue
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DOI：
10.1080/01902140701481054
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发表时间：
2007-06-01
影响因子：
1.7
通讯作者：
Marc, Janja
中科院分区：
文献类型：
--
作者：
Cerne, Darko;Melkic, Enver;Marc, Janja
作者检验了这样一个假设，即与邻近的明显健康的肺组织相比，肺癌组织中脂蛋白脂酶（LPL）基因表达和酶活性增加。从42例可切除的非小细胞肺癌患者中收集肺癌组织和癌旁肺组织的配对样本。LPL活性在癌组织中较高（1.9倍，中位数差异，P <0.0001）;然而，LPL基因表达在非癌组织中较高（3.8倍，中位数差异，P <0.0001）。肺癌组织中较高的LPL活性为增加肿瘤生长所必需的脂质营养物的供应提供了可能的机制。
The authors tested the hypothesis that lipoprotein lipase (LPL) gene expression and enzyme activity are increased in lung cancer tissue, as compared to adjacent, apparently healthy, lung tissue. Paired samples of lung cancer tissue and adjacent noncancer lung tissue were collected from 42 patients with resectable non-small cell lung cancer. LPL activity was higher in cancer tissue (1.9-fold median difference, P < .0001); however, LPL gene expression was higher in noncancer tissue (3.8-fold, median difference, P < .0001). The higher LPL activity in lung cancer tissue provides a possible mechanism for increasing the supply of lipid nutrients to the tumor, necessary for tumor growth.