Implementation of genomics research in Africa: challenges and recommendations.
Implementation of genomics research in Africa: challenges and recommendations.
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DOI：
10.1080/16549716.2017.1419033
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发表时间：
2018
影响因子：
2.6
通讯作者：
Ngomi N
中科院分区：
文献类型：
--
作者：
Adebamowo SN;Francis V;Tambo E;Diallo SH;Landouré G;Nembaware V;Dareng E;Muhamed B;Odutola M;Akeredolu T;Nerima B;Ozumba PJ;Mbhele S;Ghanash A;Wachinou AP;Ngomi N
背景：非洲对基因组学研究的兴趣和实施呈指数增长。非洲人类遗传与健康倡议促进了这一增长，该倡议旨在促进采用当代研究方法，研究非洲人口常见疾病的基因组学和环境决定因素。 目的：本文的目的是描述影响非洲基因组学研究实施的重要挑战。 研究方法：本文中提出的意见、挑战和建议是通过非洲科学家在电话会议和面对面会议上的讨论、联合会会议上的研讨会以及深入的个人讨论获得的。 结果如下：影响非洲基因组学研究实施的挑战与资源有限有关，包括设施设备不良、难以进入研究中心、缺乏专业知识以及当地医院开展研究活动的有利环境。与研究有关的挑战包括资金延迟、需要多次访问的广泛程序和干预措施、建立研究小组的延迟和工作人员培训不足、语言障碍和对文化规范认识不足。虽然许多非洲国家正在努力启动基因组学项目，但其他国家已经建立了符合国际标准的基因组学研究设施。 结论：在非洲实施成功的基因组学项目的经验教训，建议作为克服这些挑战的战略。这些建议可以指导在低资源环境下开发和应用新的研究项目。
Background: There is exponential growth in the interest and implementation of genomics research in Africa. This growth has been facilitated by the Human Hereditary and Health in Africa (H3Africa) initiative, which aims to promote a contemporary research approach to the study of genomics and environmental determinants of common diseases in African populations. Objective: The purpose of this article is to describe important challenges affecting genomics research implementation in Africa. Methods: The observations, challenges and recommendations presented in this article were obtained through discussions by African scientists at teleconferences and face-to-face meetings, seminars at consortium conferences and in-depth individual discussions. Results: Challenges affecting genomics research implementation in Africa, which are related to limited resources include ill-equipped facilities, poor accessibility to research centers, lack of expertise and an enabling environment for research activities in local hospitals. Challenges related to the research study include delayed funding, extensive procedures and interventions requiring multiple visits, delays setting up research teams and insufficient staff training, language barriers and an underappreciation of cultural norms. While many African countries are struggling to initiate genomics projects, others have set up genomics research facilities that meet international standards. Conclusions: The lessons learned in implementing successful genomics projects in Africa are recommended as strategies to overcome these challenges. These recommendations may guide the development and application of new research programs in low-resource settings.
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影响因子：
56.9
作者：
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通讯作者：
Cox, DR
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