PHYSIOLOGICAL VARIATIONS OF SERUM TESTOSTERONE WITHIN THE NORMAL RANGE DO NOT AFFECT SERUM PROSTATE-SPECIFIC ANTIGEN
PHYSIOLOGICAL VARIATIONS OF SERUM TESTOSTERONE WITHIN THE NORMAL RANGE DO NOT AFFECT SERUM PROSTATE-SPECIFIC ANTIGEN
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DOI：
10.1016/s0090-4295(99)80159-9
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发表时间：
1995-07-01
期刊：
影响因子：
2.1
通讯作者：
JAROW, JP
中科院分区：
文献类型：
--
作者：
MONATH, JR;MCCULLOUGH, DL;JAROW, JP
目标。为了确定内源性血清总睾酮水平与血清前列腺特异性抗原（PSA）浓度之间的关系，如果这两个参数之间存在相关性，那么使用睾酮特异性参考范围可能会增强PSA作为前列腺癌标志物的效用。方法：资料来自150名无前列腺癌病史的男性。PSA采用雅培IMX微粒子酶免疫法测定，总睾酮采用Coat-A-Count放射免疫法测定。结果：睾酮和PSA之间没有相关性，即使校正了年龄和体重。结论：数据提示测定血清总睾酮水平并不能提高PSA作为肿瘤标志物的敏感性或特异性。
Objectives. To determine the relationship between endogenous total serum testosterone levels and serum prostate-specific antigen (PSA) concentrations, If a correlation exists between these two parameters, then use of testosterone-specific reference ranges may enhance the utility of PSA as a marker for prostate cancer.Methods, Data were obtained from 150 men without previous history of prostate cancer. PSA was measured by the Abbott IMX microparticle enzyme immunoassay and total testosterone determined by the Coat-A-Count radioimmunoassay.Results, No correlation was found between testosterone and PSA, even when corrected for age and weight.Conclusions, The data suggest that determination of the total serum testosterone level does not improve the sensitivity or specificity of PSA as a tumor marker.