Modulation of hippocampal plasticity in learning and memory
Modulation of hippocampal plasticity in learning and memory
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DOI：
10.1016/j.conb.2022.102558
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发表时间：
2022-06-02
影响因子：
5.7
通讯作者：
Paulsen, Ole
中科院分区：
文献类型：
--
作者：
Fuchsberger, Tanja;Paulsen, Ole
突触可塑性在学习记忆的神经机制研究中起着重要作用。可塑性规则并不是随时间而不变的，而是在神经调节的控制下，使行为状态能够影响记忆的形成。神经调节在网络水平通过引导信息流来控制突触可塑性，在回路水平通过改变兴奋/抑制平衡来控制突触可塑性，并且在突触水平通过调节细胞内信号级联来控制突触可塑性。虽然大多数研究都集中在主神经元的调制，但最近的进展发现，中间神经元不仅在路由信息中发挥重要作用，而且还为突触可塑性创造条件。此外，星形胶质细胞已被证明可以门控和介导可塑性。这些额外的机制必须考虑到学习和记忆的全面机制的理解。
Synaptic plasticity plays a central role in the study of neural mechanisms of learning and memory. Plasticity rules are not invariant over time but are under neuromodulatory control, enabling behavioral states to influence memory formation. Neuromodulation controls synaptic plasticity at network level by directing information flow, at circuit level through changes in excitation/inhibition balance, and at synaptic level through modulation of intracellular signaling cascades. Although most research has focused on modulation of principal neurons, recent progress has uncovered important roles for inter neurons in not only routing information, but also setting conditions for synaptic plasticity. Moreover, astrocytes have been shown to both gate and mediate plasticity. These additional mechanisms must be considered for a comprehensive mechanistic understanding of learning and memory.