CRITICAL CLOSING PRESSURE OF VESSELS SUPPLYING THE CAPILLARY LOOPS OF THE NAILFOLD
CRITICAL CLOSING PRESSURE OF VESSELS SUPPLYING THE CAPILLARY LOOPS OF THE NAILFOLD
复制标题
DOI：
10.1161/01.res.6.4.461
复制
发表时间：
1958-01-01
影响因子：
20.1
通讯作者：
KRISMAN, AM
中科院分区：
文献类型：
--
作者：
GASKELL, P;KRISMAN, AM
血管的临界关闭压(CCP)被估计为数字收缩压与手指上的气压之间的差值，以防止血细胞在毛细血管环中流动。用听诊法估计收缩压，用直接显微镜检查检测血管环内血流的存在或消失。该方法是有效的，并不是简单地测量局部血管内压或某个流变学因素。6名受试者在加热和降温时的平均CCP分别为40和13 mm Hg。麻醉指神经可使3例受试者的CCP降低约50%。10例高血压病患者在调节性血管收缩和血管扩张时的平均CCP分别为52和19 mm Hg，而相应的平均值分别为28和19 mm Hg。年龄相仿的6名正常受试者为12毫米汞。高血压患者较大的CCP表明，较小血管的收缩张力异常高至少是这些患者外周阻力异常高的部分原因。
The critical closing pressure (CCP) of the vessels was estimated as the difference between the digital systolic blood pressure and the air pressure required on the finger to just prevent flow of blood cells in the capillary loops. Systolic pressure was estimated by an auscultatory method and presence or absence of flow in the loops was detected by direct microscopic examination. The method is valid and does not simply measure a local intravascular pressure or some rheologic factor. In 6 subjects the mean CCP was 40 and 13 mm Hg when they were heated and cooled respectively. Anesthesia of the digital nerves reduced the CCP by about 50% in 3 subjects. The mean CCP for a group of 10 patients with essential hypertension was 52 and 19 mm Hg during regulated vasoconstriction and vasodilatation respectively compared to the corresponding means of 28 and. 12 mm Hg for a group of 6 normal subjects of comparable age. The greater CCP in the hypertensives indicates that an unusually high constrictor tone in the smaller vessels is at least partially responsible for the abnormally high peripheral resistance in these patients.