HtrA, RseP, and Tsp proteins do not elicit a pathology-related serum IgG response during sexually transmitted infection with Chlamydia trachomatis
HtrA, RseP, and Tsp proteins do not elicit a pathology-related serum IgG response during sexually transmitted infection with Chlamydia trachomatis
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DOI：
10.1016/j.jri.2010.02.007
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发表时间：
2010-06-01
影响因子：
3.4
通讯作者：
Timms, Peter
中科院分区：
文献类型：
--
作者：
Huston, Wilhelmina M.;Armitage, Charles W.;Timms, Peter
沙眼衣原体性传播感染可引起严重的生殖疾病。本研究确定了血清IgG对女性沙眼原体推定应激反应蛋白的反应，以检测其与生殖道病理的关系。血清IgG反应与沙眼衣原体HtrA、Tsp或RseP与感染或病理无显著关联。与IgG阴性不育对照组相比，cHSP60血清IgG患病率与感染显著相关，但与上生殖道病理无关。与这些抗原反应的血清IgG（1-4）抗体亚类在队列之间没有显著差异，尽管检测到对每种抗原的不同反应。爱思唯尔爱尔兰有限公司版权所有版权所有。
Chlamydia trachomatis sexually transmitted infection can cause serious reproductive morbidities. This study determined the prevalence of a serum IgG response to C trachomatis putative stress response proteins in women, to test for an association with genital tract pathology. There was no significant association of serum IgG reactive with C trachomatis HtrA, Tsp, or RseP with infection or pathology. cHSP60 serum IgG prevalence was significantly associated with infection compared to IgG negative infertile controls, but not with upper genital tract pathology. Serum IgG(1-4) antibody subclasses reactive with these antigens was not significantly different between cohorts, although different responses to each antigen were detected. Crown Copyright (C) 2010 Published by Elsevier Ireland Ltd. All rights reserved.