Tabernaesines A–I, Cytotoxic Aspidosperma–Aspidosperma-Type Bisindole Alkaloids from Tabernaemontana pachysiphon
Tabernaesines A–I, Cytotoxic Aspidosperma–Aspidosperma-Type Bisindole Alkaloids from Tabernaemontana pachysiphon
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Tabernaesines A–I，细胞毒性 Aspidosperma — 来自 Tabernaemontana pachysiphon 的 Aspidosperma 型双吲哚生物碱
DOI：
10.1021/acs.jnatprod.9b00768
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发表时间：
2020
影响因子：
5.1
通讯作者：
Xiao-Jiang Hao
中科院分区：
文献类型：
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作者：
Wen-Fang Yi;Xiao Ding;Yuan-Zhi Chen;Tiwalade A. Adelakun;Yu Zhang;Xiao-Jiang Hao
从粗管山椒（Tabernaemontana pachysiphon）中分离得到21个盾叶-盾叶生物碱，其中包括新的盾叶生物碱A-J（1-9）。通过高分辨质谱和核磁共振实验确定了化合物的结构和绝对构型。化合物1 - 9的单体单元之间含有一个罕见的螺杂环结构，而化合物4和5的特征是吲哚环与一个（N，N-二乙基）甲基氨基稠合。化合物1、5- 7、15和16对多种人癌细胞系表现出中等的细胞毒性，IC 502.5 -9.8 μM。
Twenty-one aspidosperma–aspidosperma alkaloids, including the new tabernaesines A–J (1–9), were obtained fromTabernaemontana pachysiphon. The structures and absolute configurations were elucidated using HRMS and NMR experiments. Compounds1–9possessed a rare spiro heterocycle moiety between the monomeric units, while compounds4and5were characterized by an indole ring fused with an (N,N-diethyl)methyl amino group. Compounds1,5–7,15, and16exhibited moderate cytotoxic potency against various human cancer cell lines at IC502.5–9.8 μM.