Neurotransmitter transporters synthesis and degradation rates.
Neurotransmitter transporters synthesis and degradation rates.
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神经递质转运蛋白的合成和降解率。
DOI：
10.1016/s0024-3205(01)01004-9
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发表时间：
2001
期刊：
影响因子：
6.1
通讯作者：
Kuhar,MJ
中科院分区：
文献类型：
--
作者：
Kimmel,H;Vicentic,A;Kuhar,MJ
多巴胺和5-羟色胺转运蛋白的合成速率，半衰期和降解速率常数已被确定使用RTI-76，在转运蛋白的配体结合的不可逆抑制剂，和一个模型，假设合成速率是零级和降解速率是一级过程。RTI-76失活后转运蛋白恢复的半衰期约为2-3天，与其他突触蛋白相似。
The synthesis rate, half-life and degradation rate constant of dopamine and serotonin transporter proteins have been determined using RTI-76, an irreversible inhibitor of ligand binding at transporters, and a model assuming that synthesis rate is zero order and degradation rate is a first order process. The half-lives of transporter recovery after inactivation with RTI-76 are approximately 2–3 days, which are similar to those for other synaptic proteins.