Influence of Hemoglobin Concentration on Stroke Recurrence and Composite Vascular Events
Influence of Hemoglobin Concentration on Stroke Recurrence and Composite Vascular Events
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DOI：
10.1161/strokeaha.119.028058
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发表时间：
2020-04-01
期刊：
影响因子：
8.3
通讯作者：
Han, Moon-Ku
中科院分区：
文献类型：
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作者：
Chang, Jun Young;Lee, Ji Sung;Han, Moon-Ku
背景和目的：我们评估了入院时血红蛋白浓度是否与急性缺血性stroke. Methods中的卒中复发和复合血管事件（卒中、心肌梗死和血管性死亡）相关，我们从韩国多中心卒中登记数据库中收集了急性缺血性卒中或短暂性脑缺血发作患者的数据。血红蛋白浓度与1年卒中复发和复合血管事件的相关性在年龄、脑动脉狭窄、卒中严重程度和卒中亚型方面进行了评估。结果血红蛋白水平与卒中复发和复合血管事件呈负相关。贫血或中度贫血患者的一年卒中复发率和复合血管事件发生率显著较高。在多变量分析中，中度贫血仍然是卒中复发（校正风险比，1.43 [95%CI，1.16-1.75]）和复合血管事件（校正风险比，1.26 [95%CI，1.07-1.48]）的独立预测因子。中度贫血增加了轻度至中度卒中患者发生复合血管事件的风险（国立卫生研究院卒中量表评分
Background and Purpose-We evaluated whether hemoglobin concentration at admission was associated with stroke recurrence and composite vascular events (stroke, myocardial infarction, and vascular death) in acute ischemic stroke.Methods-We collected data from patients with acute ischemic stroke or transient ischemic attack from a multicenter stroke registry database in Korea. The association of hemoglobin concentration with 1-year stroke recurrence and composite vascular events was evaluated with respect to age, presence of cerebral artery stenosis, stroke severity, and stroke subtype.Results-Hemoglobin levels were inversely associated with stroke recurrence and composite vascular events. One-year rates of stroke recurrence and composite vascular events were significantly higher in patients with anemia or moderate anemia. In multivariable analyses, moderate anemia remained an independent predictor of stroke recurrence (adjusted hazard ratio, 1.43 [95% CI, 1.16-1.75]) and composite vascular events (adjusted hazard ratio, 1.26 [95% CI, 1.07-1.48]). Moderate anemia increased the risk of composite vascular events in patients with mild-to-moderate stroke severity (National Institutes of Health Stroke Scale score