Alcohol exposure during development alters hypothalamic neurotransmitter concentrations.
Alcohol exposure during development alters hypothalamic neurotransmitter concentrations.
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发育过程中接触酒精会改变下丘脑神经递质浓度。
DOI：
10.1007/bf01292616
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Kelly,SJ
中科院分区：
文献类型：
--
作者：
Kelly,SJ
The effect of exposure to alcohol during a period roughly equivalent to the human third trimester on neurotransmitter content in the rat hypothalamus was examined. The alcohol exposure was accomplished via an artificial rearing procedure. The alcohol group was exposed to 5 g/kg/day of ethanol from postnatal day (PD) 4 to 10. There was an artificially reared control group not exposed to alcohol and a normally reared control group. Noradrenaline, dopamine, homovanillic acid (HVA), 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin, and 5-hydroxyindoleacetic acid (5-HIAA) concentrations were measured using high performance liquid chromatography with electrochemical detection in juvenile and adult rats. There were no effects in juvenile rats. In adult rats, alcohol exposure from PD 4 to 10 increased hypothalamic content of noradrenaline, dopamine, serotonin and 5-HIAA. While adult females had greater amounts of hypothalamic serotonin and 5-HIAA than adult males, there were no interactions of sex with alcohol exposure. These results suggest that hypothalamic function is seriously disrupted by alcohol exposure during development.
