HOX GENE-PRODUCTS MODULATE THE DNA-BINDING ACTIVITY OF PBX1 AND PBX2
HOX GENE-PRODUCTS MODULATE THE DNA-BINDING ACTIVITY OF PBX1 AND PBX2
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hox 基因产物调节 pbx1 和 pbx2 的 DNA 结合活性
DOI：
10.1016/0925-4773(95)00394-g
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发表时间：
1995-07-01
影响因子：
2.6
通讯作者：
MURRE, C
中科院分区：
文献类型：
--
作者：
VANDIJK, MA;PELTENBURG, LTC;MURRE, C
最近发现了一个新的同源结构域蛋白家族，包括牙外环、CEH-20和三种哺乳动物蛋白Pbx1、Pbx2和Pbx3。我们在这里展示了该家族的两个成员Pbx1和Pbx2与Hoxb-7和Hoxb-8与DNA协同结合。Engrailed-2调节PBX蛋白与不同靶点的DNA结合活性。E2A-Pbx1是一种与Pre-B急性淋巴母细胞白血病相关的嵌合Pbx1基因产物，它保持了与Hox蛋白相互作用的能力。这些数据表明脊椎动物的HOX和PBX基因产物具有与DNA协同结合的能力。
A new family of homeodomain proteins has recently been identified that includes extradenticle, ceh-20 and three mammalian proteins Pbx1, Pbx2 and Pbx3. We show here that two members of this family, Pbx1 and Pbx2 bind cooperatively to DNA with both Hoxb-7 and Hoxb-8. Engrailed-2 modulates the DNA binding activity of the Pbx proteins to a different target site. E2A-Pbx1, a chimeric Pbx1 gene product involved in pre-B acute lymphoblastoid leukemia, has retained its ability to interact with the Hox proteins. These data show that vertebrate Hox and Pbx gene products have the ability to bind cooperatively to DNA.