MAPK-dependent hormonal signaling plasticity contributes to overcoming Bacillus thuringiensis toxin action in an insect host
MAPK-dependent hormonal signaling plasticity contributes to overcoming Bacillus thuringiensis toxin action in an insect host
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MAPK依赖性激素信号可塑性有助于克服昆虫宿主中苏云金芽孢杆菌毒素的作用
DOI：
10.1038/s41467-020-16608-8
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发表时间：
2020-06-12
影响因子：
16.6
通讯作者：
Zhang, Youjun
中科院分区：
文献类型：
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作者：
Guo, Zhaojiang;Kang, Shi;Zhang, Youjun
昆虫病原细菌与其昆虫宿主之间的军备竞赛是解码宿主-病原体相互作用的复杂协同进化过程的一个很好的模型。在这里，我们证明了MAPK信号通路是一个通用的开关，以反式调节氨肽酶N和其他中肠基因的差异表达的昆虫宿主，小菜蛾（小菜蛾），从而对抗苏云金芽孢杆菌（Bt）毒素的毒力效应。此外，MAPK级联被两种主要的昆虫激素20-羟基蜕皮激素（20 E）和保幼激素（JH）之间的串扰激活和微调，以引起重要的生理反应（即Bt抗性），而不会产生通常与病原体抗性相关的显著的适应性成本。众所周知，激素在各种生物中协调生理权衡，我们的工作解码了这些经典激素迄今未描述的功能，并表明激素信号可塑性是抵御病原体的一般跨王国策略。
The arms race between entomopathogenic bacteria and their insect hosts is an excellent model for decoding the intricate coevolutionary processes of host-pathogen interaction. Here, we demonstrate that the MAPK signaling pathway is a general switch to trans-regulate differential expression of aminopeptidase N and other midgut genes in an insect host, diamondback moth (Plutella xylostella), thereby countering the virulence effect of Bacillus thuringiensis (Bt) toxins. Moreover, the MAPK cascade is activated and fine-tuned by the crosstalk between two major insect hormones, 20-hydroxyecdysone (20E) and juvenile hormone (JH) to elicit an important physiological response (i.e. Bt resistance) without incurring the significant fitness costs often associated with pathogen resistance. Hormones are well known to orchestrate physiological trade-offs in a wide variety of organisms, and our work decodes a hitherto undescribed function of these classic hormones and suggests that hormonal signaling plasticity is a general cross-kingdom strategy to fend off pathogens.