ECTOPIC PRODUCTION OF PLACENTA- SPECIFIC TISSUE PROTEINS (PP5 AND PP11) BY MALIGNANT BREAST-TUMORS
ECTOPIC PRODUCTION OF PLACENTA- SPECIFIC TISSUE PROTEINS (PP5 AND PP11) BY MALIGNANT BREAST-TUMORS
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DOI：
10.1007/bf02110028
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
BOHN, H
中科院分区：
文献类型：
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作者：
INABA, N;RENK, T;BOHN, H
利用酶桥免疫过氧化物酶（PAP）技术，在16例乳腺癌中研究了2种新的胎盘特异性组织蛋白PP5和PP11的免疫组织化学定位。PP5阳性率为62.5%，PP11阳性率为46.7%。PP5和PP11可能是乳腺癌的标志物，并且在乳腺癌患者血清中检测这些蛋白质可能比测定SP1、PP10或PP12（其它妊娠特异性蛋白质）更可靠，并且在乳腺癌患者的检测和监测中更有用。
With use of an enzyme-bridge immunoperoxidase (PAP) technique, an immunohistochemical localization of the 2 new placenta-specific tissue proteins, PP5 and PP11, was investigated in 16 [human] cases of breast cancer. PP5 was localized in the cytoplasm of breast cancer cells in 62.5% of cases examined and PP11, in 46.7%. PP5 and PP11 may be markers for breast cancer and the detection of these proteins in sera from breast cancer patients may be more reliable and useful in the detection and monitoring of breast cancer patients than the determination of SP1, PP10, or PP12, other pregnancy specific proteins.