On the influence of baseline startle reactivity on the indexation of prepulse inhibition
On the influence of baseline startle reactivity on the indexation of prepulse inhibition
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DOI：
10.1037/0735-7044.122.4.885
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发表时间：
2008-08-01
影响因子：
1.9
通讯作者：
Quednow, Boris B.
中科院分区：
文献类型：
--
作者：
Csomor, Philipp A.;Vollenweider, Franz X.;Quednow, Boris B.
惊吓反射的预脉冲抑制（PPI）是指在强烈的脉冲刺激出现之前不久有弱的预脉冲刺激时，反射性惊吓反应的减少。PPI被认为是感觉运动门控的跨物种翻译模型，并且在许多神经精神疾病中已经报道了PPI缺乏。尽管部分文献基于PPI独立于基线惊起反应的假设，但越来越多的证据（Csomor et al., 2006; Sandner & Canal, 2007; Yee, Chang, Pietropaolo, & Feldon, 2005）反对这种独立性。作者系统地研究了健康人类志愿者和C57BL/6小鼠的基线惊吓反应程度是否取决于PPI指数的百分比或差异评分。结果显示，PPI的两个指数都受到基线惊吓程度的影响。作者强调了不同方法对PPI进行索引的缺陷，特别是当受惊反应性在比较组之间有很大差异时，并提供了实用的建议来令人满意地处理这种基线差异。
Prepulse inhibition (PPI) of the startle reflex refers to the reduction of the reflexive startle response to an intense pulse stimulus when its presentation is shortly preceded by a weak prepulse stimulus. PPI is considered as a cross-species translational model of sensorimotor gating, and deficient PPI has been reported in a number of neuropsychiatric disorders. Although a part of the literature is based on the assumption that PPI is independent of the baseline startle reaction, there is accumulating evidence (Csomor et al., 2006; Sandner & Canal, 2007; Yee, Chang, Pietropaolo, & Feldon, 2005) that argues against such an independency. The authors systematically investigated whether PPI indexed as percentage or difference score is dependent on the magnitude of baseline startle reactivity in healthy human volunteers and in C57BL/6 mice. The results revealed that both indexations of PPI were affected by the magnitude of the baseline startle. The authors highlight the pitfalls of different methods to index PPI, especially when startle reactivity differs considerably between groups under comparison, and offer practical recommendations to satisfactorily deal with such baseline differences.